Dec 28, 2010

Real-time electrogram analysis for monitoring coronary blood flow during human ventricular fibrillation: implications for CPR

Heart Rhythm : the Official Journal of the Heart Rhythm Society
Karthikeyan UmapathyKumaraswamy Nanthakumar

Abstract

Effective chest compressions during prolonged ventricular fibrillation (VF) have been shown to increase the chances of successful defibrillation to a rhythm associated with a sustainable cardiac output. There is currently no effective method of recording the degree of antegrade coronary artery flow during chest compression in VF. This study sought to quantify the relationship between the antegrade coronary flow and the characteristics of human VF using near real-time wavelet-based electrocardiographic markers. VF experiments were conducted in 8 isolated human hearts. The Langendorff perfusion enabled different flow rates (perfusion) during VF, which allowed for the simulation of chest compression with different efficacies. After the initiation of VF, the hearts were maintained in ischemia (no flow) for 3 minutes, followed by a 2-minute reperfusion and defibrillation. The experiments were repeated at flows of 0%, 30%, and 100% of baseline perfusion, and volume-conducted surface electrograms were recorded and analyzed using continuous wavelet transform in 5-second frames. Near real-time wavelet features were derived that demonstrated significant differences in the multicomponent nature of VF signals and predicted perfusion rate c...Continue Reading

Mentioned in this Paper

Coronary Circulation
Ischemia
Ventricular Fibrillation
Amsacrine
Pseudo brand of pseudoephedrine
Transcription Initiation
Basic Cardiac Life Support
Entire Coronary Artery
Blood Flow
Anterior Thoracic Region

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