Real-time estimation of plasma insulin concentration from continuous glucose monitor measurements

Computer Methods in Biomechanics and Biomedical Engineering
Diego de PeredaJorge Bondia

Abstract

Continuous glucose monitors can measure interstitial glucose concentration in real time for closed-loop glucose control systems, known as artificial pancreas. These control systems use an insulin feedback to maintain plasma glucose concentration within a narrow and safe range, and thus to avoid health complications. As it is not possible to measure plasma insulin concentration in real time, insulin models have been used in literature to estimate them. Nevertheless, the significant inter- and intra-patient variability of insulin absorption jeopardizes the accuracy of these estimations. In order to reduce these limitations, our objective is to perform a real-time estimation of plasma insulin concentration from continuous glucose monitoring (CGM). Hovorka's glucose-insulin model has been incorporated in an extended Kalman filter in which different selected time-variant model parameters have been considered as extended states. The observability of the original Hovorka's model and of several extended models has been evaluated by their Lie derivatives. We have evaluated this methodology with an in-silico study with 100 patients with Type 1 diabetes during 25 h. Furthermore, it has been also validated using clinical data from 12 insul...Continue Reading

References

Jun 1, 1985·Diabetologia·J Radziuk, H L Lickley
Feb 28, 2001·Diabetes, Obesity & Metabolism·J E Gerich
Sep 24, 2004·Physiological Measurement·Roman HovorkaMalgorzata E Wilinska
Nov 13, 2004·Metabolism: Clinical and Experimental·Malgorzata E WilinskaRoman Hovorka
Mar 2, 2005·Diabetes Technology & Therapeutics·Edward J Knobbe, Bruce Buckingham
Apr 15, 2010·Diabetes Technology & Therapeutics·Andrea FacchinettiClaudio Cobelli
Oct 12, 2010·Bio Systems·Claudia Eberle, Christoph Ament
Aug 26, 2011·Diabetes Technology & Therapeutics·Fátima Barceló-RicoPaolo Rossetti
Apr 7, 2012·IEEE Transactions on Bio-medical Engineering·S D PatekUNKNOWN International Artificial Pancreas (iAP) Study Group
Jun 30, 2012·Computer Methods and Programs in Biomedicine·Diego de PeredaJorge Bondia

❮ Previous
Next ❯

Citations

Mar 24, 2018·Journal of Diabetes Science and Technology·Iman HajizadehAli Cinar

❮ Previous
Next ❯

Software Mentioned

Matlab

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Computer Methods and Programs in Biomedicine
J Fernandez de CaneteJ C Ramos-Diaz
Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Yinghui LuJaques Reifman
Journal of Diabetes Science and Technology
Stephen PatekBoris P Kovatchev
© 2021 Meta ULC. All rights reserved