Real-time fMRI amygdala neurofeedback positive emotional training normalized resting-state functional connectivity in combat veterans with and without PTSD: a connectome-wide investigation

NeuroImage. Clinical
Masaya MisakiJerzy Bodurka

Abstract

Self-regulation of brain activation using real-time functional magnetic resonance imaging neurofeedback (rtfMRI-nf) is an emerging approach for treating mood and anxiety disorders. The effect of neurofeedback training on resting-state functional connectivity warrants investigation as changes in spontaneous brain activation could reflect the association between sustained symptom relief and brain alteration. We investigated the effect of amygdala-focused rtfMRI-nf training on resting-state functional connectivity in combat veterans with and without posttraumatic stress disorder (PTSD) who were trained to increase a feedback signal reflecting left amygdala activity while recalling positive autobiographical memories (Zotev et al., 2018). The analysis was performed in three stages: i) first, we investigated the connectivity in the left amygdala region; ii) next, we focused on the abnormal resting-state functional connectivity identified in our previous analysis of this data (Misaki et al., 2018); and iii) finally, we performed a novel data-driven longitudinal connectome-wide analysis. We introduced a longitudinal multivariate distance matrix regression (MDMR) analysis to comprehensively examine neurofeedback training effects beyond ...Continue Reading

References

Apr 1, 1979·The British Journal of Psychiatry : the Journal of Mental Science·S A Montgomery, M Asberg
Oct 1, 1995·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·B BiswalJ S Hyde
Jul 14, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·G H GloverD Ress
Sep 11, 2003·Current Opinion in Neurobiology·A D Craig
May 4, 2005·Trends in Cognitive Sciences·Kevin N Ochsner, James J Gross
Oct 11, 2005·Journal of Psychiatric Research·R A LaniusC Pain
Aug 8, 2006·Annals of the New York Academy of Sciences·Lisa M ShinRoger K Pitman
Aug 19, 2007·Journal of Abnormal Psychology·Jutta JoormannIan H Gotlib
Jun 1, 2010·Brain Structure & Function·Vinod Menon, Lucina Q Uddin
Nov 27, 2010·Journal of Psychiatric Research·Peggy L St JacquesDavid C Rubin
Dec 21, 2010·Trends in Cognitive Sciences·Amit EtkinRaffael Kalisch
Oct 25, 2011·NeuroImage·Nikolaus Weiskopf
Nov 26, 2011·NeuroImage·Sheng Zhang, Chiang-shan R Li
Jun 8, 2012·PloS One·David E J LindenRainer Goebel
Jun 29, 2012·Biology of Mood & Anxiety Disorders·Jasmeet P HayesAmanda M Mikedis
Jan 1, 2011·Biology of Mood & Anxiety Disorders·Alan N SimmonsMartin P Paulus
Oct 3, 2012·Annals of the New York Academy of Sciences·Kevin N OchsnerJason T Buhle
Oct 11, 2012·Nature Reviews. Neuroscience·Roger K PitmanIsrael Liberzon
Dec 5, 2012·Brain and Cognition·Matthew G WhalleyChris R Brewin
May 7, 2013·Neuroscience Letters·Xiaodan YanCharles R Marmar
Jun 15, 2013·Cerebral Cortex·Jason T BuhleKevin N Ochsner
Aug 10, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Vanessa M BrownRajendra A Morey
Nov 26, 2013·Acta Psychiatrica Scandinavica·R C KluetschR A Lanius
Jan 17, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Amanda V UtevskyScott A Huettel
Feb 18, 2014·NeuroImage·Anderson M WinklerThomas E Nichols
Jul 2, 2014·Neuroscience and Biobehavioral Reviews·D W FrankD Sabatinelli
Dec 3, 2014·NeuroImage·Jonathan D PowerSteven E Petersen
Apr 12, 2015·Biological Psychiatry·J Paul HamiltonIan H Gotlib

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Citations

Feb 20, 2020·Military Medicine·Mulugu V Brahmajothi, Mohamed B Abou-Donia
Nov 19, 2019·Frontiers in Psychiatry·Leon Skottnik, David E J Linden
Oct 9, 2020·European Journal of Psychotraumatology·A VergerE Guedj
Dec 4, 2020·Neuroscience and Biobehavioral Reviews·Monika I Roydeva, Antje A T S Reinders

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Methods Mentioned

BETA
MDMR
SMA

Software Mentioned

AFNI
nf
Analysis of Functional NeuroImages ( AFNI )
RETROICOR
rtfMRI
FSL
nlme
Advanced Normalization Tools ( ANTs )
R Core Team
R

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