Real-time fMRI neurofeedback training to improve eating behavior by self-regulation of the dorsolateral prefrontal cortex: A randomized controlled trial in overweight and obese subjects

NeuroImage
Simon H KohlManfred Hallschmid

Abstract

Obesity is associated with altered responses to food stimuli in prefrontal brain networks that mediate inhibitory control of ingestive behavior. In particular, activity of the dorsolateral prefrontal cortex (dlPFC) is reduced in obese compared to normal-weight subjects and has been linked to the success of weight-loss dietary interventions. In a randomized controlled trial in overweight/obese subjects, we investigated the effect on eating behavior of volitional up-regulation of dlPFC activity via real-time functional magnetic resonance imaging (fMRI) neurofeedback training. Thirty-eight overweight or obese subjects (BMI 25-40 kg/m2) took part in fMRI neurofeedback training with the aim of increasing activity of the left dlPFC (dlPFC group; n = 17) or of the visual cortex (VC/control group; n = 21). Participants were blinded to group assignment. The training session took place on a single day and included three training runs of six trials of up-regulation and passive viewing. Food appraisal and snack intake were assessed at screening, after training, and in a follow-up session four weeks later. Participants of both groups succeeded in up-regulating activity of the targeted brain area. However, participants of the control group a...Continue Reading

Citations

Jun 20, 2019·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Ralf VeitStephanie Kullmann
Apr 9, 2020·Psychosomatic Medicine·Shannon D DonofryKirk I Erickson
Sep 7, 2019·Nutrients·Rachel C AdamsNatalia S Lawrence
Dec 22, 2020·Frontiers in Behavioral Neuroscience·Junaid S MerchantElliot T Berkman
Jan 29, 2021·Frontiers in Neuroscience·Halim I BaqapuriKlaus Mathiak
Dec 22, 2019·NeuroImage·Michelle HampsonJunichi Ushiba
Dec 5, 2021·Reviews in Endocrine & Metabolic Disorders·Theresa Ester, Stephanie Kullmann
Dec 24, 2021·Pediatric Obesity·Jennifer R SadlerSusan Carnell

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