Real-time imaging of T-cell development

Current Opinion in Immunology
Philippe Bousso

Abstract

The cellular and molecular dynamics underlying intrathymic T-cell development are still poorly understood. Dynamic imaging techniques offer new opportunities for dissecting the complex journey of developing T cells in the thymus. In particular, two-photon laser scanning microscopy has recently demonstrated great promise in tracking lymphocyte behavior in tissue environments. Resolving thymocyte behavior at the single-cell level should help to clarify the mode of trafficking in the thymus and identify the spatio-temporal aspects of thymic selection events.

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Citations

Jun 8, 2006·Histochemistry and Cell Biology·Peter RedeckerTobias M Böckers
Oct 23, 2012·Journal of Bioscience and Bioengineering·Tsunehito HigashiSachihiro Matsunaga
May 6, 2008·The Journal of Pain : Official Journal of the American Pain Society·Diane T Stephenson, Stephen P Arneric
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Mar 20, 2018·Frontiers in Immunology·Narges Aghaallaei, Baubak Bajoghli

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