Real-Time In Vivo Characterization of Primary Liver Tumors With Diffuse Optical Spectroscopy During Percutaneous Needle Interventions: Feasibility Study in Woodchucks

Investigative Radiology
Rami NachabéJohn M Racadio

Abstract

This study presents the first in vivo real-time optical tissue characterization during image-guided percutaneous intervention using near-infrared diffuse optical spectroscopy sensing at the tip of a needle. The goal of this study was to indicate transition boundaries from healthy tissue to tumors, namely, hepatic carcinoma, based on the real-time feedback derived from the optical measurements. Five woodchucks with hepatic carcinoma were used for this study. The woodchucks were imaged with contrast-enhanced cone beam computed tomography with a flat panel detector C-arm system to visualize the carcinoma in the liver. In each animal, 3 insertions were performed, starting from the skin surface toward the hepatic carcinoma under image guidance. In 2 woodchucks, each end point of the insertion was confirmed with pathologic examination of a biopsy sample. While advancing the needle in the animals under image guidance such as fluoroscopy overlaid with cone beam computed tomography slice and ultrasound, optical spectra were acquired at the distal end of the needles. Optical tissue characterization was determined by translating the acquired optical spectra into clinical parameters such as blood, water, lipid, and bile fractions; tissue o...Continue Reading

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Citations

Sep 25, 2016·Seminars in Oncology·Ralph E Parchment, James H Doroshow
Dec 3, 2016·Lasers in Medical Science·Lisanne L de BoerTheo J M Ruers
Jan 1, 2016·Lasers in Surgery and Medicine·Crispin SchneiderBrian R Davidson
Dec 20, 2019·Biomedical Optics Express·Elisabeth J M BaltussenBehdad Dashtbozorg
Jun 25, 2021·World Journal of Gastrointestinal Oncology·Manasa Suresh, Stephan Menne

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