Real-time In Vivo Tissue Characterization with Diffuse Reflectance Spectroscopy during Transthoracic Lung Biopsy: A Clinical Feasibility Study

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Jarich W SpliethoffTheodoor J M Ruers

Abstract

This study presents the first in vivo real-time tissue characterization during image-guided percutaneous lung biopsies using diffuse reflectance spectroscopy (DRS) sensing at the tip of a biopsy needle with integrated optical fibers. Tissues from 21 consented patients undergoing lung cancer surgery were measured intraoperatively using the fiber-optic platform capable of assessing various physical tissue properties highly correlated to tissue architecture and composition. In addition, the method was tested for clinical use by performing DRS tissue sensing during 11 routine biopsy procedures in patients with suspected lung cancer. We found that water content and scattering amplitude are the primary discriminators for the transition from healthy lung tissue to tumor tissue and that the reliability of these parameters is not affected by the amount of blood at the needle tip. In the 21 patients measured intraoperatively, the water-to-scattering ratio yielded a 56% to 81% contrast difference between tumor and surrounding tissue. Analysis of the 11 image-guided lung biopsy procedures showed that the tissue diagnosis derived from DRS was diagnostically discriminant in each clinical case. DRS tissue sensing integrated into a biopsy need...Continue Reading

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Citations

Jul 10, 2016·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Jarich W SpliethoffTheodoor J M Ruers
Sep 25, 2016·Seminars in Oncology·Ralph E Parchment, James H Doroshow
Nov 12, 2016·Scientific Reports·Konstantin A RumyantsevVladislav V Verkhusha
Dec 3, 2016·Lasers in Medical Science·Lisanne L de BoerTheo J M Ruers
Dec 31, 2017·Journal of Biomedical Optics·Stephen A BoppartHenricus J C M Sterenborg
Oct 5, 2018·Journal of Oncology Practice·Katherine V Ferry-GalowAlice P Chen
Oct 28, 2017·Journal of Biomedical Optics·Elisabeth J M BaltussenTheo J M Ruers
Feb 1, 2019·Journal of Biomedical Optics·Elisabeth J M BaltussenTheo J M Ruers
Feb 26, 2019·Biomedical Optics Express·Matthieu DuperronPeter O'brien
Dec 21, 2018·Journal of Translational Medicine·Lisanne L de BoerTheo J M Ruers
Nov 10, 2018·Laryngoscope Investigative Otolaryngology·Gerrit C LanghoutTheo J M Ruers
Sep 26, 2019·Methods and Applications in Fluorescence·Jenu V Chacko, Kevin W Eliceiri
Dec 20, 2019·Biomedical Optics Express·Elisabeth J M BaltussenBehdad Dashtbozorg
Aug 28, 2020·Scientific Reports·Viktor DreminAndrey Dunaev
Oct 21, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Joachim G Aerts
Jul 11, 2021·Journal of Biophotonics·Eladio Rodriguez-DiazIrving J Bigio

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