Real-time Kt/V determination by ultraviolet absorbance in spent dialysate: technique validation

Kidney International
Alex CastellarnauMarten Jakob

Abstract

Real-time determination of Kt/V can be provided by monitoring ultraviolet absorbance of solutes in spent dialysate. This not only overcomes dependency on error-prone pre- and post-dialysis blood sampling; it circumvents inaccuracies associated with estimating the urea distribution volume and its high measurement frequency tightly reflects the course of the dialysis. Our study compared the ultraviolet-based spKt/V and eKt/V with the commonly used blood-based counterparts. A first study of 16 patients compared ultraviolet Kt/Vs against blood Kt/Vs obtained by using the 'gold standard' of serial blood samples. A second study included 18 patients and compared the ultraviolet and blood values under routine conditions. Both studies showed mean blood-based spKt/V and eKt/V values statistically indistinguishable from their ultraviolet-based counterparts. Hence, on-line monitoring of ultraviolet absorption of spent dialysate is applicable in routine hemodialysis allowing continuous measure of removed solutes from spent dialysate without disturbing the patient or treatment session.

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Citations

May 13, 2014·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Ruth TomsonIvo Fridolin
Dec 27, 2012·IEEE Transactions on Bio-medical Engineering·Ivo FridolinRaimund Ubar
Sep 23, 2016·Expert Review of Medical Devices·Manoj K SharmaJeroen P Kooman
Apr 13, 2018·The International Journal of Artificial Organs·Ahmed Mohamed, Andrew Davenport
Jan 26, 2018·Journal of Renal Care·Aarne Vartia
Mar 19, 2014·The International Journal of Artificial Organs·Taoufiq AatifZouhair Oualim
Aug 20, 2019·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Kai LauriIvo Fridolin
Feb 6, 2020·The International Journal of Artificial Organs·Jörn MeibaumChristof Strohhöfer
Jan 6, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Linda DingMaury N Pinsk
Feb 3, 2021·Seminars in Dialysis·Thierry Petitclerc, Christophe Ridel
Dec 15, 2020·Jornal brasileiro de nefrologia : ʹorgão oficial de Sociedades Brasileira e Latino-Americana de Nefrologia·Mauro Sergio Martins MarrocosSandra Maria Rodrigues
Nov 24, 2021·The International Journal of Artificial Organs·Li ZhangXiangmei Chen

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