Real-time measurement of kidney tubule fluid nitric oxide concentrations in early diabetes: disparate changes in different rodent models

Nitric Oxide : Biology and Chemistry
David Z Levine, Michelle Iacovitti

Abstract

There are several reports indicating that nitric oxide (NO) plays a role in the kidney hyperfiltration seen in the early stages of diabetes mellitus (DM). Whole kidney GFR and single nephron GFR (SNGFR) have been reported to decrease after nitric oxide synthase (NOS) inhibition. To date, no direct, in vivo, quantitative NO measurements have been made within the kidney in any models of early diabetes. To assess the possible association of changes in tubular fluid nitric oxide concentrations (TF [NO]) with early diabetes, a specially modified NO electrode with a tip diameter of about 7 microm was used to measure NO in single tubules in seven rodent groups. In the Sprague-Dawley (SD) rat model, TF [NO] increased by 50% after streptozotocin (STZ) induced DM1. In the B6129G2/J mouse, control TF [NO] was more than twice the rat control value and fell by 50% after STZ treatment. In three other groups of mice-db/db (B6.Cg-m+/+Lepr(db)/J) Type II diabetic (DM2) mouse, db/m (its heterozygote), and the corresponding wild type (WT)-TF [NO] was also much higher than in the rat, and unlike the B6129G2/J STZ diabetic mouse, did not change after the onset of diabetes. Blood glucose concentrations were similar in the three diabetic groups. Acco...Continue Reading

References

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Oct 20, 2004·Nitric Oxide : Biology and Chemistry·Radko KomersSharon Anderson

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Citations

May 5, 2006·Current Hypertension Reports·David Z Levine
Feb 2, 2008·Methods in Enzymology·Ian R Davies, Xueji Zhang
Mar 31, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Liselotte PihlFredrik Palm
Apr 3, 2015·Physiological Reviews·Mattias CarlströmWilliam J Arendshorst
Sep 21, 2007·American Journal of Physiology. Renal Physiology·Haikun ShiJoseph Winaver

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