Real-Time MEG Source Localization Using Regional Clustering

Brain Topography
C DinhM S Hämäläinen

Abstract

With its millisecond temporal resolution, Magnetoencephalography (MEG) is well suited for real-time monitoring of brain activity. Real-time feedback allows the adaption of the experiment to the subject's reaction and increases time efficiency by shortening acquisition and off-line analysis. Two formidable challenges exist in real-time analysis: the low signal-to-noise ratio (SNR) and the limited time available for computations. Since the low SNR reduces the number of distinguishable sources, we propose an approach which downsizes the source space based on a cortical atlas and allows to discern the sources in the presence of noise. Each cortical region is represented by a small set of dipoles, which is obtained by a clustering algorithm. Using this approach, we adapted dynamic statistical parametric mapping for real-time source localization. In terms of point spread and crosstalk between regions the proposed clustering technique performs better than selecting spatially evenly distributed dipoles. We conducted real-time source localization on MEG data from an auditory experiment. The results demonstrate that the proposed real-time method localizes sources reliably in the superior temporal gyrus. We conclude that real-time source ...Continue Reading

References

Jan 1, 1994·Medical & Biological Engineering & Computing·M S Hämäläinen, R J Ilmoniemi
Jan 1, 1995·Journal of Neural Transmission. General Section·C M MichelD Lehmann
Sep 23, 2003·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·A TarkiainenR Salmelin
Oct 15, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Stephanie R JonesChristopher I Moore
Jun 21, 2011·Computational Intelligence and Neuroscience·Gustavo SudreDouglas J Weber
Jan 18, 2012·NeuroImage·Bruce Fischl
Sep 18, 2013·Biomedizinische Technik. Biomedical Engineering·Christoph DinhMatti S Hamalainen
Oct 29, 2013·NeuroImage·Alexandre GramfortMatti S Hämäläinen

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Citations

Apr 20, 2016·IEEE Transactions on Medical Imaging·Daniel StrohmeierAlexandre Gramfort
Apr 29, 2018·Brain Topography·Alireza Talesh Jafadideh, Babak Mohammadzadeh Asl
Jul 18, 2017·IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society·Dheeraj RatheeHubert Cecotti
Jun 3, 2017·The Review of Scientific Instruments·Limin SunMatti Hämäläinen
Sep 8, 2017·Brain Topography·Christoph DinhJens Haueisen
Apr 6, 2018·Journal of Neuroscience Methods·Lorenz EschChristoph Dinh
Mar 27, 2021·Frontiers in Neuroscience·Christoph DinhSheraz Khan
May 5, 2021·CNS Neuroscience & Therapeutics·Li-Juan ShiJi-Cong Zhang

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