Real time monitoring of aminothiol level in blood using a near-infrared dye assisted deep tissue fluorescence and photoacoustic bimodal imaging

Chemical Science
Palapuravan AneesYanli Zhao

Abstract

The development of molecular probes for the detection and imaging of biological thiols is a major step forward diagnosing various types of diseases. Previously reported thiol imaging strategies were mainly based on a single mode of imaging with a limited application in vivo. In this work, we introduced an unsymmetrical near-infrared (NIR) squaraine dye (USq) as an exogenous contrast agent for photoacoustic and fluorescence bimodal imaging of thiol variations in live animals. USq exhibits a narrow absorption band at 680 nm that generates a photoacoustic signal and a strong NIR emission at 700 nm (ΦF = 0.27), which is applicable for deep tissue optical imaging. Both photoacoustic and fluorescence signals could selectively disappear in the presence of different thiols. Through in vitro and in vivo imaging studies, unique imaging capability of USq was demonstrated, and the effect of food uptake on the increased level of aminothiols in blood was confirmed.

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Citations

Oct 17, 2018·Chemical Communications : Chem Comm·Lucien LavaudOlivier Siri
May 10, 2020·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Qi FanBo Peng
Apr 5, 2017·Chemistry : a European Journal·Giridharan SaranyaAyyappanpillai Ajayaghosh
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Apr 30, 2021·Analytical Methods : Advancing Methods and Applications·Huihui MeiLi Yang
Jun 8, 2021·Chemical Science·Sandip ChakrabortyAyyappanpillai Ajayaghosh
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Oct 29, 2019·Journal of the American Chemical Society·Zhongyan ChenWeijiang He
Oct 16, 2019·Analytical Chemistry·Gongcheng MaJing Lin
Dec 28, 2017·Bioconjugate Chemistry·Deepak S ChauhanRohit Srivastava

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Methods Mentioned

BETA
imaging techniques
column
NMR
fluorescence imaging
fluorescence microscopy

Software Mentioned

viewMSOT
IVIS Living Imaging

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