Real-time myocardial glucose measurement using biosensors

ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs
Daniel S EifermanR Anthony Perez-Tamayo

Abstract

During ischemia, myocardial fatty acid metabolism ceases, rapidly depleting the other primary fuel, glucose. No technique has existed to continuously monitor myocardial glucose. Needle-tip enzymatic glucose biosensors have been developed for subcutaneous use in diabetic management. To study the utility of these sensors for real-time myocardial glucose monitoring in clinically relevant applications, 40 kg Yorkshire swine were cannulated for cardiopulmonary bypass. Biosensors were placed in the left anterior descending artery distribution (LAD) and posterior descending artery distribution (PD), and a third in the liver. Selective ischemia was induced by ligation of the LAD artery. Glucose levels were monitored during ischemia and reperfusion in the setting of cardioplegic arrest (n = 7) and in the normal beating heart (n = 14). In the normal beating heart, glucose levels fall to 6.5% +/- 7.4% baseline at 1 minute and 29.0% +/- 23.0% at 5 minutes of ischemia. In both arrested and beating heart scenarios, biosensors show distinct metabolic states in specific regions of the heart and liver. Biosensors can track regional glucose metabolism in the beating and arrested heart. This novel application of these sensors allows real-time det...Continue Reading

References

Dec 10, 1999·The Annals of Thoracic Surgery·G CohenV Rao
Jan 16, 2002·The Annals of Thoracic Surgery·S F Khuri
Jan 16, 2002·The Annals of Thoracic Surgery·K R KhabbazK G Warner
Jan 17, 2002·The New England Journal of Medicine·G van den BergheR Bouillon

❮ Previous
Next ❯

Citations

Aug 21, 2015·Applied Psychophysiology and Biofeedback·Paloma González-CastroLuis Álvarez

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.