Real-Time Neuron Detection and Neural Signal Extraction Platform for Miniature Calcium Imaging

Frontiers in Computational Neuroscience
Yaesop LeeShuvra S Bhattacharyya

Abstract

Real-time neuron detection and neural activity extraction are critical components of real-time neural decoding. In this paper, we propose a novel real-time neuron detection and activity extraction system using a dataflow framework to provide real-time performance and adaptability to new algorithms and hardware platforms. The proposed system was evaluated on simulated calcium imaging data, calcium imaging data with manual annotation, and calcium imaging data of the anterior lateral motor cortex. We found that the proposed system accurately detected neurons and extracted neural activities in real time without any requirement for expensive, cumbersome, or special-purpose computing hardware. We expect that the system will enable cost-effective, real-time calcium imaging-based neural decoding, leading to precise neuromodulation.

References

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Methods Mentioned

BETA
PCA
Extraction
feature extraction

Software Mentioned

Motion Correction
Neuron Detection and Signal Extraction Platform ( NDSEP )
CellSort
PND
SimpleBlobDetector
Sourcery
OS High Sierra
Mac
- SIFT
HNCcorr

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