Real-Time Study of the Interaction between G-Rich DNA Oligonucleotides and Lead Ion on DNA Tetrahedron-Functionalized Sensing Platform by Dual Polarization Interferometry

ACS Applied Materials & Interfaces
Shuang WangXiurong Yang

Abstract

G-quadruplex plays roles in numerous physiological and pathological processes of organisms. Due to the unique properties of G-quadruplex (e.g., forming G4/hemin complexes with catalytic activity and electron acceptability, binding with metal ions, proteins, fluorescent ligands, and so on), it has been widely applied in biosensing. But the formation process of G-quadruplex is not yet fully understood. Here, a DNA tetrahedron platform with higher reproducibility, regenerative ability, and time-saving building process was coupled with dual polarization interferometry technique for the real-time and label-free investigation of the specific interaction process of guanine-rich singled-stranded DNA (G-rich ssDNA) and Pb2+. The oriented immobilization of probes greatly decreased the spatial hindrance effect and improved the accessibility of the probes to the Pb2+ ions. Through real-time monitoring of the whole formation process of the G-quadruplex, we speculated that the probes on the tetrahedron platform initially stood on the sensing surface with a random coil conformation, then the G-rich ssDNA preliminarily formed unstable G-quartets by H-bonding and cation binding, subsequently forming a completely folded and stable quadruplex str...Continue Reading

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Citations

Jan 25, 2019·Chemical Communications : Chem Comm·Shuang WangXiurong Yang
Mar 8, 2019·Advanced Healthcare Materials·Divita Mathur, Igor L Medintz
Nov 27, 2020·Chembiochem : a European Journal of Chemical Biology·Chenyu JiangPeng Miao
Dec 9, 2020·Sensors·Shuang WangYe Tian
Jul 25, 2021·International Journal of Molecular Sciences·Shuang WangYe Tian
May 4, 2018·ACS Sensors·Fan YangChunhai Fan

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