Real-time Volumetric Assessment of the Human Carotid Artery: Handheld Multispectral Optoacoustic Tomography

Radiology
Ivana IvankovicDaniel Razansky

Abstract

Background Multispectral optical imaging has the capability of resolving hemoglobin, lipid, and water. Volumetric multispectral optoacoustic tomography (MSOT) is a hybrid imaging technique that provides a unique combination of functional and molecular contrast with real-time handheld imaging. Purpose To investigate whether volumetric MSOT can provide real-time assessment of the anatomic and functional status of the human carotid artery bifurcation noninvasively. Materials and Methods Imaging of healthy volunteers (n = 16) was performed with a custom-designed handheld volumetric MSOT scanner capable of high-spatial-resolution (approximately 200 µm) and real-time (10 volumes/sec) three-dimensional imaging, while further providing spectroscopic capacity through fast tuning of the excitation light wavelength. For comparison and anatomic cross-validation, volunteers were also scanned with clinical B-mode US. Results Volumetric MSOT achieved real-time imaging and characterization of the entire carotid bifurcation area across three dimensions simultaneously captured in a single volumetric image frame. Analysis of the acquired data further showed that a higher contrast-to-noise ratio can be achieved for wavelengths corresponding to a h...Continue Reading

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Citations

Feb 1, 2019·Journal of Biophotonics·Benedict Mc LarneyDaniel Razansky
May 3, 2019·Physics in Medicine and Biology·Sophinese Iskander-RizkGijs van Soest
Mar 5, 2020·Molecular and Cellular Pediatrics·Adrian P RegensburgerFerdinand Knieling
Dec 5, 2019·Biomedical Optics Express·Shuangyang ZhangWufan Chen
Jul 26, 2019·Physics in Medicine and Biology·Xosé Luís Deán-Ben, Daniel Razansky
May 1, 2020·International Journal of Molecular Sciences·Jean Michel MerkesSrinivas Banala
Feb 18, 2021·European Journal of Nuclear Medicine and Molecular Imaging·Daniel RazanskyRuiqing Ni
May 1, 2021·Biomedicines·Adrian P RegensburgerFerdinand Knieling
May 15, 2021·Experimental Dermatology·Xosé Luís Deán-Ben, Daniel Razansky
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Aug 31, 2021·Biomedical Optics Express·Jan-Willem MullerRichard Lopata
Aug 12, 2021·British Journal of Pharmacology·Neil MacRitchiePasquale Maffia

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