Real-time volumetric image reconstruction and 3D tumor localization based on a single x-ray projection image for lung cancer radiotherapy

Medical Physics
Ruijiang LiSteve B Jiang

Abstract

To develop an algorithm for real-time volumetric image reconstruction and 3D tumor localization based on a single x-ray projection image for lung cancer radiotherapy. Given a set of volumetric images of a patient at N breathing phases as the training data, deformable image registration was performed between a reference phase and the other N-1 phases, resulting in N-1 deformation vector fields (DVFs). These DVFs can be represented efficiently by a few eigenvectors and coefficients obtained from principal component analysis (PCA). By varying the PCA coefficients, new DVFs can be generated, which, when applied on the reference image, lead to new volumetric images. A volumetric image can then be reconstructed from a single projection image by optimizing the PCA coefficients such that its computed projection matches the measured one. The 3D location of the tumor can be derived by applying the inverted DVF on its position in the reference image. The algorithm was implemented on graphics processing units (GPUs) to achieve real-time efficiency. The training data were generated using a realistic and dynamic mathematical phantom with ten breathing phases. The testing data were 360 cone beam projections corresponding to one gantry rotatio...Continue Reading

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Citations

Sep 24, 2013·Computer Vision and Image Understanding : CVIU·Chen-Rui ChouStephen Pizer
Aug 26, 2011·Physics in Medicine and Biology·Ruijiang LiSteve B Jiang
Dec 17, 2010·Medical Physics·Chunhua MenSteve B Jiang
Jul 13, 2012·Zeitschrift für medizinische Physik·Geoffrey D Hugo, Mihaela Rosu
Apr 29, 2014·IEEE Transactions on Medical Imaging·Jian-Feng CaiHongkai Zhao
Feb 1, 2014·IEEE Transactions on Image Processing : a Publication of the IEEE Signal Processing Society·Geert Van EyndhovenJan Sijbers
Apr 29, 2014·IEEE Transactions on Medical Imaging·Qingyu ZhaoStephen Pizer
Oct 12, 2013·International Journal of Radiation Oncology, Biology, Physics·Ruijiang LiBilly W Loo
Dec 17, 2014·International Journal of Computer Assisted Radiology and Surgery·Wen Pei LiuRussell H Taylor
Mar 31, 2015·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·You ZhangLei Ren
Jul 2, 2015·Medical Physics·Weixing CaiJohn H Lewis
May 17, 2015·Medical Physics·Xiaoyong ZhangMakoto Yoshizawa
Aug 31, 2010·International Journal of Radiation Oncology, Biology, Physics·Dimitre HristovHuy M Do
Nov 11, 2016·IEEE Transactions on Medical Imaging·You ZhangJing Wang
May 1, 2016·International Journal of Radiation Oncology, Biology, Physics·Wendy HarrisFang-Fang Yin
Jun 2, 2017·Physics in Medicine and Biology·Ander BiguriManuchehr Soleimani
Nov 14, 2018·Medical Physics·Shinichiro MoriKikuo Umegaki
Dec 22, 2012·Physics in Medicine and Biology·Jing Wang, Xuejun Gu
Feb 4, 2014·Physics in Medicine and Biology·Xun JiaSteve B Jiang
Apr 26, 2016·Biomedical Physics & Engineering Express·Guang LiJoseph O Deasy
Feb 19, 2019·Physics in Medicine and Biology·G CheeJ H Lewis
Dec 31, 2014·Physics in Medicine and Biology·Martina HurwitzJohn H Lewis
Dec 20, 2015·Physics in Medicine and Biology·Weixing CaiJohn H Lewis
Aug 8, 2014·Physics in Medicine and Biology·Xiaoyong ZhangMakoto Yoshizawa

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