Real-World Analysis of Therapeutic Patterns in Patients Affected by Rheumatoid Arthritis in Italy: A Focus on Baricitinib

Rheumatology and Therapy
Valentina PerroneLuca Degli Esposti

Abstract

The objective of this study was to evaluate treatment patterns in patients with rheumatoid arthritis (RA), with a focus on the utilization of baricitinib, an oral highly selective Janus kinase 1 and 2 inhibitor, in an Italian real-world setting. This observational retrospective analysis was based on data collected in selected Italian administrative databases. Patients aged ≥ 18 years with a diagnosis of RA defined by hospitalization discharge diagnosis (International Classification of Diseases, Ninth Revision, Clinical Modification code 714.0) or by disease exemption code 006 for RA in 2018 were included. The index date (ID) was defined as the date of first prescription for a drug indicated for RA during the inclusion period. Patients without a prescription for biologic/targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARDs) before the ID were considered to be b/tsDMARD naïve. A further analysis was performed on patients only receiving baricitinib. A total of 41,290 RA patients were enrolled, of whom 55.6% were not treated with conventional synthetic DMARDs (csDMARDs) or b/tsDMARDs, 39.4% were receiving therapy with csDMARDs, and 5.0% were using b/tsDMARDs. In the latter group, 2.7% (n = 56) were receiving therapy...Continue Reading

References

Sep 28, 2010·Lancet·David L ScottTom W J Huizinga
Oct 30, 2016·Lancet·Josef S SmolenIain B McInnes
Mar 16, 2017·Drugs·Anthony Markham
Jul 3, 2019·Journal of Clinical Medicine·Birgit M KöhlerHanns-Martin Lorenz
Dec 18, 2019·Annals of the Rheumatic Diseases·Josef S Smolen

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Citations

Jun 3, 2021·International Journal of Environmental Research and Public Health·Valentina PerroneLuca Degli Esposti

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