"Real-World" Application of Thrombolysis in Cardiac Arrest.

Journal of Pharmacy Practice
Susan E Smith, Daniel C Johnson

Abstract

Current guidelines recommend consideration of thrombosis as a reversible cause of cardiac arrest. The use of thrombolytic therapy during cardiac arrest, however, is controversial. We sought to characterize the use of thrombolytic therapy during cardiac arrest and to evaluate the rate of return of spontaneous circulation (ROSC) in a "real-word" setting. A single-center, retrospective, cohort study of adult patients who received alteplase during cardiac arrest between 2010 and 2015 were performed at a tertiary academic medical center. Twenty-six patients were identified. Patients were predominantly male (65%) and Caucasian (89%) and were a median age of 64 years. Five patients had a history of preexisting venous thromboembolism, and eight patients were receiving systemic anticoagulation. Pulmonary embolism was confirmed prior to the administration of alteplase in 5 patients. The median dose of alteplase administered was 100 mg. ROSC was achieved in 65% of patients, 2 of whom survived to hospital discharge. Both surviving patients experienced a bleeding event. In a single center's experience, thrombolytic therapy is used infrequently for the management of cardiac arrest. Thrombolysis during cardiac arrest should be considered on a...Continue Reading

References

Apr 1, 1991·Journal of Internal Medicine·T Silfvast
Jun 5, 1997·The New England Journal of Medicine·C M SpauldingP Carli
May 17, 2002·The New England Journal of Medicine·Riyad B Abu-LabanVictor M Wood
Jun 3, 2004·Resuscitation·Daniel M FatovichRichard A Clugston
Dec 19, 2008·The New England Journal of Medicine·Bernd W BöttigerUNKNOWN European Resuscitation Council Study Group
Jul 31, 2014·The American Journal of Emergency Medicine·Qin YinChunsheng Li
Jul 17, 2016·The American Journal of Emergency Medicine·Mohsen SharifiUNKNOWN “PEAPETT” investigators

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