Real-World Data on Prognostic Factors for Overall Survival in EGFR Mutation-Positive Advanced Non-Small Cell Lung Cancer Patients Treated with First-Line Gefitinib

The Oncologist
Zong-Han YaoChong-Jen Yu

Abstract

This study aimed to identify independent prognostic factors for overall survival (OS) of patients with advanced non-small cell lung cancer (NSCLC) harboring an activating epidermal growth factor receptor (EGFR) mutation and receiving gefitinib as first-line treatment in real-world practice. We enrolled 226 patients from June 2011 to May 2013. During this period, gefitinib was the only EGFR-tyrosine kinase inhibitor reimbursed by the Bureau of National Health Insurance of Taiwan. The median progression-free survival and median OS were 11.9 months (95% confidence interval [CI]: 9.7-14.2) and 26.9 months (21.2-32.5), respectively. The Cox proportional hazards regression model revealed that postoperative recurrence, performance status (Eastern Cooperative Oncology Grade [ECOG] ≥2), smoking index (≥20 pack-years), liver metastasis at initial diagnosis, and chronic hepatitis C virus (HCV) infection were independent prognostic factors for OS (hazard ratio [95% CI] 0.3 [0.11-0.83], p = .02; 2.69 [1.60-4.51], p < .001; 1.92 [1.24-2.97], p = .003; 2.26 [1.34-3.82], p = .002; 3.38 [1.85-7.78], p < .001, respectively). However, brain metastasis (BM) at initial diagnosis or intracranial progression during gefitinib treatment had no impact o...Continue Reading

References

Oct 31, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Bruce R Bacon
Feb 10, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Gregory J RielyVincent A Miller
Apr 4, 2008·Liver International : Official Journal of the International Association for the Study of the Liver·Faisal M SanaiKhalid I Bzeizi
Dec 23, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E A EisenhauerJ Verweij
Aug 21, 2009·The New England Journal of Medicine·Tony S MokMasahiro Fukuoka
Mar 2, 2010·The Journal of Infectious Diseases·Chyng-Wen FwuChien-Jen Chen
Oct 5, 2010·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Lars Haukali OmlandUNKNOWN DANVIR Cohort Study
Mar 3, 2011·International Journal of Cancer. Journal International Du Cancer·Robert R Langley, Isaiah J Fidler
Mar 15, 2011·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Lisa I BackusLarry A Mole
Jun 18, 2011·Liver International : Official Journal of the International Association for the Study of the Liver·William SievertFrancesco Negro
Dec 15, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Mariam Jamal-Hanjani, James Spicer
Dec 29, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Paul W SperdutoMinesh Mehta
Jan 31, 2012·The Lancet Oncology·Rafael RosellUNKNOWN Spanish Lung Cancer Group in collaboration with Groupe Français de Pneumo-Cancérologie and Associazione Italiana Oncologia T
Jul 19, 2012·Cancer Chemotherapy and Pharmacology·Yosuke TogashiMichiaki Mishima
Nov 7, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·Y-L WuJ-J Yang
Jul 3, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lecia V SequistMartin Schuler
Sep 21, 2013·Nature Immunology·Craig N Jenne, Paul Kubes
Mar 19, 2014·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Min Hwan KimJoo Hang Kim
Mar 10, 2015·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Kuan-Li WuMing-Shyan Huang
May 6, 2015·Journal of Hepatology·Robert D AllisonUNKNOWN Chronic Hepatitis Cohort Study (CHeCS) Investigators
Jan 27, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Yayi HeFred R Hirsch
Feb 11, 2016·Therapeutic Advances in Infectious Disease·Patrice CacoubDavid Saadoun

❮ Previous
Next ❯

Citations

Apr 9, 2020·Frontiers in Oncology·Yue-Hua ZhangYue-Min Zhou
Jul 7, 2019·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Zong-Han YaoChong-Jen Yu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer
Young Joo LeeJ S Lee
Lung Cancer : Journal of the International Association for the Study of Lung Cancer
Kuan-Li WuMing-Shyan Huang
Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer
Masayuki TakedaKazuhiko Nakagawa
© 2022 Meta ULC. All rights reserved