Real world data on young patients with high-risk diffuse large B-cell lymphoma treated with R-CHOP or R-CHOEP - MYC, BCL2 and BCL6 as prognostic biomarkers

PloS One
Mette Ølgod PedersenPeter Nørgaard

Abstract

Double expression of MYC and BCL2 proteins (DE) and double-hit MYC+BCL2/BCL6 translocations (DH) were established as important biomarkers in patients with diffuse large B-cell lymphoma (DLBCL) by the 2016 revision of the World Health Organization classification of lymphoid neoplasms. Whether this applies to the subgroup of young patients with high risk DLBCL is not known. We previously found that in a uniform retrospective population-based cohort of patients aged 18-60 years with high-risk DLBCL, the addition of etoposide to R-CHOP chemotherapy (R-CHOEP) resulted in improved survival mainly in patients with germinal center B-cell like (GCB) immunophenotype. The aim of this study was to investigate the prognostic and predictive value of DE and DH in this patient cohort. Data on all young Danish patients diagnosed with de novo high-risk DLBCL 2004-2008 and treated with R-CHOP or R-CHOEP were obtained from the Danish Lymphoma database (n = 159). Tumor samples were available from 103 patients. MYC and BCL2 proteins were analyzed with quantitative immunohistochemistry (IHC) using different cut off values. MYC-, BCL2- and BCL6-translocations were examined with fluorescent in situ hybridization (FISH). DE with MYC>75% and BCL2>85% was...Continue Reading

References

Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B D ChesonG P Canellos
Nov 1, 2005·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Anuradha KanungoPei Lin
Apr 2, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Wyndham H WilsonJohn E Janik
May 26, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sharon BarransAndrew Jack
Dec 2, 2010·Blood·Sietse M AukemaPhilip M Kluin
Apr 15, 2011·Advances in Anatomic Pathology·Graham W Slack, Randy D Gascoyne
Oct 18, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Shaoying LiL Jeffrey Medeiros
Jun 6, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Tina Marie GreenMichael Boe Møller
Aug 2, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nathalie A JohnsonRandy D Gascoyne
Nov 29, 2014·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Amer Z MahmoudMohammad A Vasef
Aug 27, 2015·Virchows Archiv : an International Journal of Pathology·Mogens Vyberg, Søren Nielsen
Sep 24, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Karla V Ballman
Nov 7, 2015·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Zijun Y Xu-MonetteKen H Young
Feb 3, 2016·American Journal of Clinical Pathology·Michael J KlukScott J Rodig
Jun 24, 2016·PloS One·Bente ArboePeter de Nully Brown

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Software Mentioned

EPOCH
DA
R
Cutoff Finder
SPSS Statistics

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