Real-world effectiveness of elbasvir/grazoprevir In HCV-infected patients in the US veterans affairs healthcare system

Journal of Viral Hepatitis
Jennifer KramerFasiha Kanwal

Abstract

Elbasvir/grazoprevir (EBR/GZR) is an all-oral direct-acting antiviral agent (DAA) with high sustained virologic response (SVR) in clinical trials. This study's primary objective was to evaluate effectiveness of EBR/GZR among HCV-infected patients in a real-world clinical setting. We conducted a nationwide retrospective observational cohort study of HCV-infected patients in the US Department of Veterans Affairs (VA) using the VA Corporate Data Warehouse. The study population included patients with positive HCV RNA who initiated EBR/GZR from February 1 to August 1, 2016. We calculated the 95% confidence interval for binomial proportions for SVR overall and by demographic subgroups. Clinical and demographic characteristics were also evaluated. We included 2436 patients in the study cohort. Most were male (96.5%), African American (57.5%), with mean age of 63.5 (SD = 5.9) and 95.4% infected with genotype (GT) 1 [GT1a (34.7%), GT1b (58.6%)]. Other comorbidities included diabetes (53.2%), depression (57.2%) and HIV (3.0%). More than 50% had history of drug or alcohol abuse (53.9% and 60.5%, respectively). 33.2% of the cohort had cirrhosis. A total of 95.6% (2,328/2,436; 95% CI: 94.7%-96.4%) achieved SVR. The SVR rates by subgroups we...Continue Reading

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Citations

Jul 9, 2020·Liver International : Official Journal of the International Association for the Study of the Liver·Julia DietzUNKNOWN European HCV Resistance Study Group
Apr 17, 2020·Infectious Diseases and Therapy·Amy PuenpatomJennifer R Kramer
Mar 11, 2020·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Sarah R LieberAlfred Sidney Barritt
May 12, 2020·Gastroenterology Clinics of North America·Ashley N Tran, Joseph K Lim
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Jun 6, 2020·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Pin-Nan ChengChun-Jen Liu

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