Real-world effectiveness of sofosbuvir plus ribavirin for chronic hepatitis C genotype 2 in Asia: a systematic review and meta-analysis

BMJ Open Gastroenterology
Bin WeiMindie H Nguyen

Abstract

Sofosbuvir plus ribavirin (SOF+RBV) for 12 weeks is the standard treatment for chronic hepatitis C (CHC) genotype 2 (GT2) in most of Asia despite availability of new CHC medications. SOF-RBV real-world effectiveness has only been reported in small and/or single-centre studies. Our goal was to determine the real-world effectiveness of 12-week SOF+RBV therapy for CHC GT2 in Asia. A systematic search on PubMed and Embase was conducted through 30 June 2017. We identified full articles and conference proceedings of at least 10 adult patients with CHC GT2 treated with SOF+RBV for 12 weeks under real-world setting in Asia. A total of 2208 patients from 13 studies were included. The pooled sustained virological response 12 weeks after the end of treatment (SVR12) was 95.8% (95% CI 94.6% to 96.9%) with non-significant heterogeneity (I2=34.4%). Anaemia (27.9%) was the most common adverse event (AE), with serious AEs in 2.0% and only 0.7% discontinued therapy prematurely. In subgroup analyses, patients with cirrhosis had 8.7% lower SVR12 than non-cirrhotic patients (P<0.0001), and treatment-experienced patients had 7.2% lower SVR12 than treatment-naïve patients (P=0.0002). Cirrhotic treatment-experienced patients had the lowest SVR12 at 8...Continue Reading

References

Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Apr 6, 2013·Alimentary Pharmacology & Therapeutics·L H Nguyen, M H Nguyen
May 6, 2014·The New England Journal of Medicine·Stefan ZeuzemUNKNOWN VALENCE Investigators
Jun 3, 2014·Systematic Reviews·Elizabeth StovoldAnna Noel-Storr
Jan 1, 2014·Archives of public health = Archives belges de santé publique·Victoria N NyagaMarc Aerts
Apr 1, 2010·Research Synthesis Methods·Michael BorensteinHannah R Rothstein
Jul 15, 2015·The Korean Journal of Internal Medicine·Seng Gee Lim, Yock Young Dan
Sep 8, 2015·Contemporary Clinical Trials·Rebecca DerSimonian, Nan Laird
Nov 17, 2015·The New England Journal of Medicine·Jordan J FeldUNKNOWN ASTRAL-1 Investigators
Nov 26, 2015·JAMA Internal Medicine·Hal F Yee
Feb 3, 2016·Liver International : Official Journal of the International Association for the Study of the Liver·Jia-Horng KaoWan-Long Chuang
May 1, 2016·Hepatology International·Masao OmataShiv Kumar Sarin
Jul 19, 2016·Liver International : Official Journal of the International Association for the Study of the Liver·Frank TackeStefan Mauss
Sep 30, 2016·World Journal of Gastroenterology : WJG·Arnolfo PetruzzielloCarmela Cacciapuoti
Oct 30, 2016·Antiviral Research·Eiichi OgawaUNKNOWN Kyushu University Liver Disease Study (KULDS) Group
Nov 9, 2016·Journal of Gastroenterology·Kei MorioUNKNOWN Hiroshima Liver Study Group
Jan 28, 2017·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Miyako MurakawaMamoru Watanabe
Feb 15, 2017·JAMA : the Journal of the American Medical Association
Apr 14, 2017·The Lancet. Gastroenterology & Hepatology·Seng Gee LimCihan Yurdaydin
Apr 14, 2017·The Lancet. Gastroenterology & Hepatology·UNKNOWN Polaris Observatory HCV Collaborators
May 14, 2017·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Masanori AtsukawaKatsuhiko Iwakiri
Jun 1, 2017·The New England Journal of Medicine·Marc BourlièreUNKNOWN POLARIS-1 and POLARIS-4 Investigators

❮ Previous
Next ❯

Citations

Jan 30, 2019·Journal of Gastroenterology and Hepatology·Chen-Hua LiuJia-Horng Kao
Feb 12, 2019·Clinical and Molecular Hepatology·Chung-Feng Huang, Ming-Lung Yu
Aug 30, 2019·Hepatology International·Chung-Feng HuangUNKNOWN REAL-C Investigators
Oct 10, 2020·World Journal of Hepatology·Hideyuki TamaiKatsuhiko Higashi

❮ Previous
Next ❯

Software Mentioned

TARGET
meta
ggplot2
R
HCV

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.