Real-world Effectiveness of Sofosbuvir/Velpatasvir for Treatment of Chronic Hepatitis C in British Columbia, Canada: A Population-Based Cohort Study

Open Forum Infectious Diseases
James WiltonNaveed Z Janjua

Abstract

Clinical trials show high efficacy of sofosbuvir/velpatasvir (SOF/VEL), but there are limited data from "real-world" settings. We aimed to evaluate SOF/VEL effectiveness for all hepatitis C virus (HCV) genotypes (GTs) in British Columbia (BC), Canada. We used the BC Hepatitis Testers Cohort, which includes all HCV cases in the province (1990-2015) linked to administrative databases, including prescriptions to end of 2018. We measured sustained virologic response (SVR; negative RNA ≥10 weeks after treatment end) and identified characteristics associated with non-SVR. Conservatively, we excluded individuals with no assessment for SVR if their last RNA test after treatment initiation was negative (but included if positive). Of 2821 eligible participants, most were infected with GT1 (1076, 38.1%) or GT3 (1072, 38.0%), and a minority (278, 9.9%) were treated with RBV. SVR was 94.6% (2670/2821) overall and 94.5% (1017/1076) for GT1, 96.4% (512/531) for GT2, and 93.7% (1004/1072) for GT3. When disaggregated by GT, treatment regimen, and cirrhosis/treatment experience, SVR was lowest (30/40, 75.0%) among treatment-experienced GT3 individuals treated with RBV. Characteristics associated with non-SVR in multivariable analysis included yo...Continue Reading

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Citations

Nov 21, 2020·Journal of Gastroenterology and Hepatology·Yu Jun WongTiing-Leong Ang
Mar 30, 2021·World Journal of Gastroenterology : WJG·Dorota Zarębska-Michaluk
May 10, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Hartwig KlinkerMarkus Cornberg
Aug 3, 2021·Expert Review of Gastroenterology & Hepatology·Chiara RubinoGiuseppe Indolfi

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