Real-world efficacy and safety of sofosbuvir + ribavirin for hepatitis C genotype 2: A nationwide multicenter study by the Japanese Red Cross Liver Study Group

Hepatology Research : the Official Journal of the Japan Society of Hepatology
Takehiro AkahaneNamiki Izumi

Abstract

This study aimed to describe the real-world efficacy and safety of sofosbuvir (SOF) + ribavirin (RBV) for chronic hepatitis C, genotype 2. This was a retrospective analysis of a nationwide, multicenter registry including 914 hepatitis C genotype 2 Japanese patients treated with SOF + RBV for 12 weeks. The rate of sustained virologic response at 12 weeks after treatment (SVR12), incidence of adverse events, and changes in serological parameters were analyzed. Treatment was completed in 98.9% of patients. Ribavirin dose reduction was required in 29.7% of patients. The SVR12 rate was 96.8% in the intention-to-treat population and 97.6% in the per-protocol population. Factors associated with SVR12 were absence of advanced fibrosis (odds ratio, 5.76, P = 0.003) and interferon-treatment-naïve status (odds ratio, 4.79, P = 0.017). Dose reduction or total adherence of RBV was not associated with SVR. The resistance-associated substitution S282 T in NS5B was not detected in any patient at virologic failure. Serum albumin levels significantly increased, and the degree of increase was greater in patients with advanced fibrosis than in those without (0.21 ± 0.32 vs. 0.05 ± 0.29, P < 0.0001). Alpha-fetoprotein decreased significantly at end...Continue Reading

References

Jun 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T TanakaM Kohara
Jun 15, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Anaïs Vallet-PichardStanislas Pol
Mar 20, 2010·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Yuko ArimaKentaro Yoshioka
Apr 9, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yasuhiro AsahinaNamiki Izumi
Apr 24, 2013·The New England Journal of Medicine·Ira M JacobsonUNKNOWN FUSION Study
Apr 24, 2013·The New England Journal of Medicine·Eric LawitzEdward J Gane
Mar 7, 2014·Epidemiology and Infection·H ToyodaJ Tanaka
May 6, 2014·The New England Journal of Medicine·Stefan ZeuzemUNKNOWN VALENCE Investigators
Jul 22, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Kazumi YamasakiHiroshi Yatsuhashi
Aug 16, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Eric F DonaldsonLisa K Naeger
Oct 1, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Evguenia S SvarovskaiaHongmei Mo
Apr 26, 2015·Journal of Hepatology·UNKNOWN European Association for Study of Liver
Oct 30, 2015·Journal of Viral Hepatitis·V LiakinaJ Gunter
Nov 18, 2015·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Eisuke MiyakiKazuaki Chayama
Nov 18, 2015·The New England Journal of Medicine·Graham R FosterUNKNOWN ASTRAL-3 Investigators
Nov 26, 2015·The Journal of Infectious Diseases·Evguenia S SvarovskaiaHongmei Mo
Feb 3, 2016·Liver International : Official Journal of the International Association for the Study of the Liver·Jia-Horng KaoWan-Long Chuang
Feb 21, 2016·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Jun ItoUNKNOWN NORTE Study Group
May 31, 2016·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Samuel B HoUNKNOWN VALOR study team
Jul 19, 2016·Liver International : Official Journal of the International Association for the Study of the Liver·Frank TackeStefan Mauss
Oct 30, 2016·Antiviral Research·Eiichi OgawaUNKNOWN Kyushu University Liver Disease Study (KULDS) Group
Jan 28, 2017·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Miyako MurakawaMamoru Watanabe
May 14, 2017·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Masanori AtsukawaKatsuhiko Iwakiri
Sep 3, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hidenori ToyodaHiromitsu Kumada
Jan 4, 2018·Liver International : Official Journal of the International Association for the Study of the Liver·Yasuhiro AsahinaNobuyuki Enomoto

❮ Previous
Next ❯

Citations

Apr 23, 2019·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Ayako UrabeTetsuo Takehara
Oct 22, 2019·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Eiichi OgawaUNKNOWN Kyushu University Liver Disease Study (KULDS) Group
Aug 25, 2020·Annals of Laboratory Medicine·Nobuharu TamakiNamiki Izumi
Jun 20, 2020·World Journal of Gastroenterology : WJG·Shereen A SalehGhada A Mohamed
Jun 19, 2019·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Atsunori KusakabeNamiki Izumi
Aug 16, 2019·World Journal of Gastroenterology : WJG·Massimo Giuseppe ColomboSanjay Hadigal
Oct 10, 2020·World Journal of Hepatology·Hideyuki TamaiKatsuhiko Higashi
Feb 6, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Nobuharu TamakiNamiki Izumi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.