Real-world evaluation of effectiveness, persistence, and usage patterns of tofacitinib in treatment of rheumatoid arthritis in Australia

Clinical Rheumatology
Paul BirdHedley Griffiths

Abstract

The aim of this study was to describe the real-world evidence for effectiveness, treatment persistence, and treatment patterns among patients in the community with rheumatoid arthritis treated with the JAK inhibitor tofacitinib. This was a retrospective, non-interventional cohort study that extracted data for new users of tofacitinib or biologic disease-modifying antirheumatic drugs (bDMARDs) from the Australian Optimizing Patient outcomes in Australian RheumatoLogy (OPAL) dataset between March 2015 and September 2018. Patients were propensity score matched at a 1:2 tofacitinib to bDMARD ratio based on age, sex, and selected baseline treatment combinations. Treatment effectiveness was evaluated using disease status measures. Treatment persistence was calculated and the percentage of patients receiving monotherapy or combination therapy at treatment initiation was evaluated. Data from 2810 patients were extracted and 1950 patients were included in the matched population (1300 bDMARD initiators and 650 tofacitinib initiators). Patients were predominantly aged 55 to 74 years (57.8%) and female (81.2%). After 18 months of treatment, 52.4% and 57.8% of patients had achieved disease activity score (DAS) remission in the bDMARD and to...Continue Reading

References

Aug 10, 2012·The New England Journal of Medicine·Roy FleischmannUNKNOWN ORAL Solo Investigators
Jun 19, 2014·The New England Journal of Medicine·Eun Bong LeeUNKNOWN ORAL Start Investigators
May 15, 2015·Annals of the Rheumatic Diseases·Josef S SmolenDesirée van der Heijde
Feb 3, 2016·Patient Related Outcome Measures·Eric G BoyceKate M O'Dell
Dec 14, 2016·The New England Journal of Medicine·Rachel E ShermanRobert M Califf
Nov 16, 2017·Drugs·Sohita Dhillon

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Citations

Jul 18, 2020·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Fowzia Ibrahim, David L Scott
Jan 3, 2021·The Journal of Rheumatology·Peter Nash
Aug 6, 2021·Open Access Rheumatology : Research and Reviews·Ilaria Bertoldi, Roberto Caporali
Sep 17, 2021·Expert Review of Clinical Immunology·Kim Lauper, Kimme L Hyrich

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