Real-World Experience With 100 Consecutive Patients Undergoing Neck Contouring With ATX-101 (Deoxycholic Acid): An Updated Report With A 2-Year Analysis

Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]
Sachin M Shridharani

Abstract

Deoxycholic acid (DCA; ATX-101) injection was approved for the treatment of mild-to-moderate convexity associated with submental fat in 2015. To evaluate the experience with DCA injections in a clinical practice setting. This ongoing, prospective, single-center, single-arm, observational study evaluated 100 consecutive patients treated with subcutaneous DCA (2 mg/cm) injections (maximum 6 sessions at ≥1-month intervals). Treatment response was assessed using the clinician-reported submental fat rating scale (CR-SMFRS) and confirmed by independent physician review of photographs at 1 and 5 to 7 weeks after treatment. Since the previous published report, 17 patients have undergone additional treatment sessions, with a total of 100 patients having undergone 195 treatment sessions: 41, 36, 14, 6, 2, and 1 patient underwent 1, 2, 3, 4, 5, and 6 sessions, respectively. Overall, 91.7% of patients in the single treatment session group and 100% in the multiple treatment session group had an improvement of ≥1 point on the CR-SMFRS. The mean (SD) duration of local edema, numbness, and tenderness after treatment was 7.1 (5.1), 27.9 (11.3), and 3.5 (3.5) days, respectively. Deoxycholic acid injections were generally well tolerated, and ≥2 t...Continue Reading

References

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Dec 18, 2015·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Derek H JonesFrederick C Beddingfield
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Apr 28, 2017·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Sachin M Shridharani
Jun 1, 2017·JAAD Case Reports·Skylar SouyoulDeirdre O'Boyle Hooper

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Citations

Aug 7, 2020·Journal of Cutaneous Medicine and Surgery·Kristy C MetzgerMelinda J Gooderham
Apr 3, 2021·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Laura Salvador, Jesús Benito-Ruiz
Jul 16, 2021·Plastic and Reconstructive Surgery. Global Open·Craig F TellerSachin M Shridharani

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