PMID: 26793407Jan 23, 2016Paper

Real-world Experience with Sofosbuvir-based Regimens for Chronic Hepatitis C, Including Patients with Factors Previously Associated with Inferior Treatment Response

Hawai'i Journal of Medicine & Public Health : a Journal of Asia Pacific Medicine & Public Health
Christina J WuNaoky C S Tsai

Abstract

The introduction of sofosbuvir, a direct acting antiviral, has revolutionized the treatment of chronic hepatitis C virus (HCV). Phase 3 clinical trials have demonstrated the efficacy, simplicity, and tolerability of sofosbuvir-based regimens and report high rates of sustained virological response (SVR) rates. The purpose of this study was to assess whether clinical trial findings translate into a real-world setting, particularly with treatment of chronic HCV in our diverse, multiethnic population of Hawai'i. Retrospective analysis was performed for 113 patients with genotype 1-6 HCV infection being treated at the Queen's Liver Center between January 2014 and March 2015. SVR rates for our cohort were slightly lower than the rates published by the clinical trials. Data analysis also suggested that most baseline characteristics previously associated with inferior response might not be as significant for sofosbuvir-based regimens; in our cohort, male gender was the only factor significantly related to increased risk of virologic relapse. Pacific Islanders also had higher rate of relapse compared to other ethnic groups, but the small number of patients treated in this subgroup make it difficult to validate this finding. While newer ...Continue Reading

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Related Papers

The New England Journal of Medicine
Nezam AfdhalION-1 Investigators
The New England Journal of Medicine
Stefan ZeuzemVALENCE Investigators
Annals of Hepatology
Décio Passos Sampaio PéresLuciana Dornelles Sampaio Péres
Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology
Ajit SoodAmarjeet Kaur
© 2022 Meta ULC. All rights reserved