Real-world impact of direct acting antiviral therapy on health-related quality of life in HIV/Hepatitis C co-infected individuals

Journal of Viral Hepatitis
Sahar SaeedCanadian Co-Infection Cohort Study Investigators

Abstract

Clinical trial results of direct acting antivirals (DAAs) for the treatment of hepatitis C virus (HCV) have shown improvements in health-related quality of life (HR-QoL). However, the extent to which these results are broadly generalizable to real-world settings is unknown. We investigated the real-world impact of oral DAA therapy on HR-QoL among individuals coinfected with HIV/HCV. We used data from the Canadian HIV/HCV Co-Infection Cohort Study that prospectively follows 1795 participants from 18 centres. Since 2007, clinical, lifestyle, and HR-QoL data have been collected biannually through self-administered questionnaires and chart review. HR-QoL was measured using the EQ-5D instrument. Participants initiating oral DAAs, having at least one visit before treatment initiation and at least one visit after DAA treatment response was ascertained, were included. Successful treatment response was defined as a sustained viral response (SVR). Segmented multivariate linear mixed models were used to evaluate the impact of SVR on HR-QoL, controlling for pretreatment trends. 227 participants met our eligibility criteria, 93% of whom achieved SVR. Before treatment, the EQ-5D utility index decreased 0.6 percentage-point/y (95% CI, -0.9, -...Continue Reading

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Citations

Jul 26, 2019·Liver International : Official Journal of the International Association for the Study of the Liver·Miao-Hui HuangShan-Chwen Chang
Nov 11, 2020·Research in Nursing & Health·Nathan F DieckmannLissi Hansen
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Aug 1, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Mirinda Ann GormleyAlain H Litwin

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