Real-world misuse, abuse, and dependence of abuse-deterrent versus non-abuse-deterrent extended-release morphine in Medicaid non-cancer patients

Postgraduate Medicine
Theodore J CiceroPeter W Park

Abstract

Opioids with abuse-deterrent properties may reduce widespread abuse, misuse, and diversion of these products. This study aimed to quantify misuse, abuse, dependence, and health resource use of extended-release morphine sulfate with sequestered naltrexone hydrochloride (ER-MSN; EMBEDA®), compared with non-abuse-deterrent extended-release morphine (ERM) products in Medicaid non-cancer patients. Administrative medical and pharmacy claims data were analyzed for 10 Medicaid states from 1 January 2015, to 30 June 2016. Patients were included if they received a prescription for ER-MSN or any oral, non-abuse-deterrent ERM. Index date was the date of first prescription for an ER-MSN or ERM. Abuse/dependence, non-fatal overdose, emergency department (ED) visits, and ED/inpatient readmissions were determined for each participant. An overall measure of misuse and abuse was also calculated. To account for differences in follow-up, all counts are expressed per 100 patient-years. There were 4,857 patients who received ER-MSN and 10,357 who received an ERM. The average age in the two cohorts was approximately 45 years old. From pre-index to follow-up, the number of patients per 100 patient-years with a diagnosis code indicating abuse or depend...Continue Reading

References

Oct 27, 2011·Journal of Addictive Diseases·Hilary SurrattTheodore J Cicero
Jul 3, 2013·The Journal of Pain : Official Journal of the American Pain Society·Stevan Geoffrey SevertsonRichard C Dart
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Jan 9, 2018·Journal of Opioid Management·Richard C DartSidney H Schnoll

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Citations

Dec 7, 2021·Pain and Therapy·Nabarun DasguptaPatricia R Freeman

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