Real-world study of a novel prognostic scoring system: for a more precise prognostication and better clinical treatment guidance in stages II and III colon cancer

International Journal of Colorectal Disease
Qi LiuXinxiang Li

Abstract

This study aimed to improve the American Joint Committee on Cancer (AJCC) Tumor Node Metastases (TNM) staging system and demonstrate the improvement in prognostic accuracy and clinical management guidance in colon cancer using the novel prognostic score (P score). Eligible patients were identified using the Surveillance, Epidemiology, and End Results database. A P score (based on age, tumor size, and tumor grade) was assigned to each patient. The Cox proportional hazards regression analyses were performed to identify independent factors associated with prognosis. The Kaplan-Meier survival curves were used to analyze the prognosis of patients with colon cancer with different P scores. The TNM staging system was compared with the P score in stages I-IV by calculating the concordance index. The multivariate Cox analysis indicated that a higher P score was independently associated with a higher risk of cancer-specific mortality. The Kaplan-Meier survival curves showed that the survival benefit gradually increased as the P score decreased. The concordance index rose from 0.5, 0.593, 0.633, and 0.551 of AJCC TNM staging system to 0.709, 0.651, 0.691, and 0.623 of P score in stages I-IV, respectively. The P score was an independent pr...Continue Reading

References

Aug 1, 1984·The British Journal of Surgery·R K PhillipsL P Fielding
May 1, 1994·The British Journal of Surgery·H E MulcahyD P O'Donoghue
Apr 7, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sharlene GillRichard M Goldberg
Jun 17, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Al B BensonDaniel G Haller
Sep 17, 2009·Journal of the National Comprehensive Cancer Network : JNCCN·Dorothy RomanusDeborah Schrag
Jan 27, 2010·American Journal of Clinical Oncology·Peter KornpratCord Langner
Jul 27, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Erin S O'ConnorMaureen A Smith
Sep 20, 2011·Journal of the American College of Surgeons·Elena A ManilichFeza H Remzi
Nov 8, 2011·Journal of the National Comprehensive Cancer Network : JNCCN·Al B BensonUNKNOWN National Comprehensive Cancer Network
Nov 16, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Martin R WeiserDeborah Schrag
Oct 30, 2012·Journal of the National Cancer Institute·Arnaud D RothEric Van Cutsem
Oct 23, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R LabiancaUNKNOWN ESMO Guidelines Working Group
Dec 5, 2013·Advances in Surgery·Elizabeth A Arena, Anton J Bilchik
Mar 19, 2014·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Nov 2, 2014·Journal of the National Cancer Institute·Lindsay A RenfroUNKNOWN Adjuvant Colon Cancer Endpoints (ACCENT) Group
Feb 26, 2016·International Journal of Cancer. Journal International Du Cancer·S R VerhoeffJ F M Pruijt
Jan 6, 2017·British Journal of Cancer·Christopher T AquinaFergal J Fleming
Apr 30, 2017·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E AuclinJ Taieb
Jun 18, 2017·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Tomoki YamanoUNKNOWN Japanese Study Group for Postoperative Follow-up of Colorectal Cancer

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