Real-world treatment patterns for patients with metastatic head and neck squamous cell carcinoma treated with immuno-oncology therapy.

Head & Neck
Ranee MehraChakkarin Burudpakdee

Abstract

Real-world use of immuno-oncology (IO) therapies (nivolumab and pembrolizumab) in metastatic head and neck squamous cell carcinoma (mHNSCC) has not been well studied. mHNSCC patients treated with an IO therapy were identified from a large US claims database from 2016 to 2017. Treatment patterns before and after initiation of IO therapy (index date) were described. Among 416 mHNSCC patients, 85% had ≥1 regimen prior to IO therapy. Ninety-seven percent of patients initiated IO as monotherapy and 3% initiated IO combined with another systemic treatment. One hundred seventeen (28%) patients had a subsequent regimen, usually chemotherapy (n = 58, 50%) or IO monotherapy (n = 27, 23%), of which 22 patients restarted the same IO therapy and 5 switched to another IO monotherapy. The majority of mHNSCC patients initiated IO as a monotherapy. Approximately half of patients with a subsequent regimen received chemotherapy and one-fourth received IO monotherapy.

References

Jul 1, 1996·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·S ShingakiT Nakajima
Jul 19, 2006·Archives of Otolaryngology--head & Neck Surgery·Werner GaravelloRenato Maria Gaini
Apr 3, 2008·Mayo Clinic Proceedings·Shanthi Marur, Arlene A Forastiere
Aug 30, 2008·International Journal of Cancer. Journal International Du Cancer·Shu-Chun ChuangMia Hashibe
Sep 12, 2008·The New England Journal of Medicine·Jan B VermorkenRicardo Hitt
Feb 26, 2011·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayDonald Maxwell Parkin
May 14, 2014·Oral Oncology·Dan P Zandberg, Scott E Strome
Sep 10, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Assuntina G Sacco, Ezra E Cohen
Sep 21, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Laura Q M ChowTanguy Y Seiwert
Oct 11, 2016·The New England Journal of Medicine·Robert L FerrisMaura L Gillison
May 4, 2017·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·V DoganC-J Busch
Jun 10, 2017·Journal of the National Comprehensive Cancer Network : JNCCN·David AdelsteinSusan D Darlow
Aug 16, 2017·Journal for Immunotherapy of Cancer·Dylan J MartiniToni K Choueiri

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