Real-world use of apremilast for patients with psoriasis in Japan

The Journal of Dermatology
Megumi KishimotoMamitaro Ohtsuki

Abstract

Apremilast is a novel oral phosphodiesterase 4 inhibitor effective for psoriasis. It regulates the production of pro-inflammatory mediators. Apremilast was approved in December 2016 in Japan; however, its efficacy and safety in a real-world setting among Japanese patients have not been reported. We report on 44 patients treated with apremilast between March and October 2017. The median treatment duration was 25 weeks (range, 2-33). Thirty-five patients (79.5%) continued the drug for at least 23 weeks, and five (11.4%) achieved a Psoriasis Area and Severity Index 100 response within 12 weeks. Nine patients discontinued the drug within 24 weeks mainly due to insufficient efficacy (n = 3) and adverse events (n = 4). Seven patients continued their previous systemic therapies such as cyclosporin (n = 1), methotrexate (n = 1), etretinate + methotrexate (n = 1) and biologics (n = 4) combined with apremilast. Of these patients, 55.9% had at least one adverse event although no severe adverse events. The most common adverse event was diarrhea (31.8%), followed by nausea (25.0%), headache (13.6%), abdominal discomfort (6.8%) and vomiting (6.8%). The proportion of diarrhea in our patients was higher than those of previous clinical trials. ...Continue Reading

References

Nov 16, 2016·Journal of Cutaneous Medicine and Surgery·Julia N Mayba, Melinda J Gooderham
Feb 19, 2017·Drugs·Gillian M Keating
Jun 18, 2017·Clinical and Experimental Dermatology·T H WongC A Morton
Sep 20, 2017·Journal of the European Academy of Dermatology and Venereology : JEADV·I VujicL Richter
Feb 2, 2018·Journal of the European Academy of Dermatology and Venereology : JEADV·E PapadavidD Rigopoulos

❮ Previous
Next ❯

Citations

Jun 11, 2019·The Journal of Dermatology·Megumi KishimotoMamitaro Ohtsuki
Oct 7, 2019·The Journal of Dermatology·Hiroshi Saruwatari
Nov 7, 2019·Scandinavian Journal of Immunology·Kazuhisa FurueMasutaka Furue
Aug 20, 2019·The British Journal of Dermatology·G Damiani
May 28, 2019·Innate Immunity·Masutaka Furue, Takafumi Kadono
Jul 23, 2020·Drugs & Aging·Céline PhanUNKNOWN GEM Resopso
Feb 20, 2020·International Journal of Molecular Sciences·Masutaka FurueTakeshi Nakahara
Jun 18, 2020·Giornale Italiano Di Dermatologia E Venereologia : Organo Ufficiale, Società Italiana Di Dermatologia E Sifilografia·Jose-Manuel Carrascosa, Elena Del-Alcazar
Nov 10, 2020·Indian Journal of Dermatology·Abhishek DeAarti Sarda
Jan 7, 2021·The Journal of Dermatology·Masaru Honma, Kei Hayashi
Apr 4, 2021·International Journal of Molecular Sciences·Andrea Picchianti-DiamantiBruno Laganà
Dec 11, 2021·Experimental Dermatology·Touraj Khosravi-HafshejaniJan P Dutz
Dec 25, 2021·Dermatology and Therapy·Masayuki TanakaTaichi Nakamura

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.