Real-world walking in multiple sclerosis: Separating capacity from behavior

Gait & Posture
Matthew M EngelhardMyla D Goldman

Abstract

Habitual physical activity (HPA) measurement addresses the impact of MS on real-world walking, yet its interpretation is confounded by the competing influences of MS-associated walking capacity and physical activity behaviors. To develop specific measures of MS-associated walking capacity through statistically sophisticated HPA analysis, thereby more precisely defining the real-world impact of disease. Eighty-eight MS and 38 control subjects completed timed walks and patient-reported outcomes in clinic, then wore an accelerometer for 7days. HPA was analyzed with several new statistics, including the maximum step rate (MSR) and habitual walking step rate (HWSR), along with conventional methods, including average daily steps. HPA statistics were validated using clinical walking outcomes. The six-minute walk (6MW) step rate correlated most strongly with MSR (r=0.863, p<10-25) and HWSR (r=0.815, p<10-11) rather than average daily steps (r=0.676, p<10-11). The combination of MSR and HWSR correlated more strongly with the 6MW step rate than either measure alone (r=0.884, p<10-14). The MSR overestimated the 6MW step rate (μ=10.4, p<10-7), whereas the HWSR underestimated it (μ=-18.2, p<10-19). Conventional HPA statistics are poor measu...Continue Reading

References

Mar 19, 2002·American Journal of Preventive Medicine·Nancy HumpelEva Leslie
Jul 13, 2002·Social Science & Medicine·Billie Giles-Corti, Robert J Donovan
Jul 27, 2005·Multiple Sclerosis : Clinical and Laboratory Research·Robert W MotlErin M Snook
Oct 19, 2007·Multiple Sclerosis : Clinical and Laboratory Research·Myla D GoldmanJeffrey A Cohen
Dec 20, 2007·Medicine and Science in Sports and Exercise·Richard P TroianoMargaret McDowell
Jan 12, 2010·Journal of the Neurological Sciences·Madeline WeikertDaniel Wynn
Nov 30, 2010·Archives of Physical Medicine and Rehabilitation·Robert W MotlMyla Goldman
Dec 24, 2010·Therapeutic Advances in Neurological Disorders·Myla D GoldmanRichard A Rudick
Mar 10, 2011·Annals of Neurology·Chris H PolmanJerry S Wolinsky
Oct 5, 2011·Medical Engineering & Physics·Madeline WeikertRobert W Motl
Dec 18, 2012·Acta Neurologica Scandinavica·R W MotlJ H Pula
May 8, 2013·BMC Public Health·Fei SunAlison E While
Aug 3, 2013·Archives of Physical Medicine and Rehabilitation·Rachel E KlarenLara A Pilutti

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Citations

Nov 2, 2018·Multiple Sclerosis : Clinical and Laboratory Research·Liesbet M PeetersPeter Feys
Jul 2, 2020·International Journal of MS Care·Kedar K V Mate, Nancy E Mayo
Jul 22, 2019·Gait & Posture·Katie L J CederbergRobert W Motl
Dec 3, 2020·International Journal of Environmental Research and Public Health·Massimiliano PauEleonora Cocco
Dec 10, 2020·International Journal of Environmental Research and Public Health·Viktoria KarleAlexander Tallner

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