Abstract
The study aims to examine real-world weight change and the role of medication adherence among patients with type 2 diabetes who initiated one of three drug classes: glucagon-like peptide-1 receptor agonist (GLP-1RA), dipeptidyl peptidase-4 inhibitor (DPP4) and sulfonylureas (SUs). A cohort of patients initiating one of the three drug classes was selected from a large US database of integrated electronic medical record and administrative claims. Adherence was defined as per cent of days covered ≥80% during the year following drug initiation. Weight change was calculated from drug initiation (-180, +30 d) to 1 year (±90 d) later. Multivariate regression controlled for baseline differences between adherent and poorly adherent patients and the addition of another drug class during follow-up. The study included 833 GLP-1RA, 2,272 DPP4 and 2,713 SU patients who contributed 2,279, 6,602 and 7,429 observations respectively. Patients initiating a GLP-1RA achieved the largest weight change (-2.46 kg of GLP-1RA, -1.26 kg of DPP4 and 0.18 kg of SU, P < 0.01). Adherent GLP-1 patients lost 1.73 kg more than poorly adherent patients, and adherent SU patients gained 1.11 kg more than poorly adherent patients (all P < 0.01). Adherent and poorly...Continue Reading
References
Sep 27, 2006·Archives of Internal Medicine·P Michael HoDavid J Magid
Mar 17, 2007·Diabetes Care·UNKNOWN Look AHEAD Research GroupSusan Z Yanovski
Nov 6, 2008·Diabetologia·K Eeg-OlofssonB Eliasson
Mar 15, 2011·Clinical Therapeutics·Carl AscheChris Conner
May 20, 2011·Diabetes Care·Rena R WingUNKNOWN Look AHEAD Research Group
Nov 16, 2011·The New England Journal of Medicine·Thomas A WaddenReneé H Moore
Nov 17, 2011·The New England Journal of Medicine·Lawrence J AppelFrederick L Brancati
Jan 13, 2012·BMJ : British Medical Journal·Tina VilsbøllLise Lotte Gluud
Apr 21, 2012·Diabetes Care·Silvio E InzucchiUNKNOWN European Association for the Study of Diabetes (EASD)
Dec 7, 2013·Obesity·UNKNOWN Look AHEAD Research Group
Jan 28, 2014·Current Therapeutic Research, Clinical and Experimental·Susan GrandyUNKNOWN SHIELD Study Group
Feb 8, 2014·Diabetes Research and Clinical Practice·Carrie McAdam-MarxDiana I Brixner
Feb 20, 2014·International Journal of Clinical Practice·J P H Wilding
Sep 24, 2014·Advances in Therapy·Abhishek S ChitnisMette Hammer
Dec 17, 2014·Advances in Therapy·Amanda M FarrIftekhar Kalsekar
Dec 30, 2014·Diabetes Care·Silvio E InzucchiDavid R Matthews
Apr 3, 2015·Advances in Therapy·Erin K BuysmanJakob Langer
Jun 11, 2015·Diabetes Research and Clinical Practice·Basem M MishrikyRobert J Tanenberg
Apr 29, 2016·Journal of Managed Care & Specialty Pharmacy·Jayanti MukherjeeStephen Johnston
Oct 8, 2016·Diabetes, Obesity & Metabolism·Sonal SinghRattan Juneja
Dec 17, 2016·Diabetes Care·UNKNOWN American Diabetes Association
Dec 17, 2016·Diabetes, Obesity & Metabolism·Zin Z HtikeMelanie J Davies
Citations
Oct 21, 2017·Diabetes, Obesity & Metabolism·Robert HenryMichelle Baron
May 6, 2019·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Carol M HamerskyNeeraj N Iyer
Aug 9, 2019·Diabetes, Obesity & Metabolism·Raffaella GentilellaPaolo Pozzilli
Nov 27, 2019·Diabetic Medicine : a Journal of the British Diabetic Association·R Dankner, J Roth
Jan 19, 2020·The Journal of Nutrition·Noor A StruikNatalie D Luscombe-Marsh
Jul 17, 2018·BMC Medicine·John WildingJesús Medina
Mar 10, 2019·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Bruno GuerciElisheva Lew
Feb 8, 2019·Journal of Managed Care & Specialty Pharmacy·Swapna KarkareNeeraj N Iyer
Sep 26, 2020·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Antonio C BossiUNKNOWN ANDREW study group
Dec 17, 2020·Journal of Diabetes·Yongquan ShiTianpei Hong
Nov 19, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Mario Luca MorieriGian Paolo Fadini
Jan 25, 2019·Diabetes & Metabolism·B GuerciB Vergès
Jul 1, 2019·Metabolism: Clinical and Experimental·Anastasia-Stefania Alexopoulos, John B Buse
May 29, 2021·Frontiers in Veterinary Science·Michael KlotsmanChen Gilor
Aug 29, 2021·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Yan ZhouQiuhe Ji