Realistic spatial sampling for MEG beamformer images

Human Brain Mapping
G R BarnesK D Singh

Abstract

The spatial resolution achievable using magnetoencephalography (MEG) beamformer techniques is inhomogeneous across the brain and is related directly to the amplitude of the underlying electrical sources [Barnes and Hillebrand, Hum Brain Mapp 2003;18:1-12; Gross et al., Proc Natl Acad Sci USA 2001;98:694-699; Van Veen et al., IEEE Trans Biomed Eng 1997;44:867-860; Vrba and Robinson, Proc 12th Int Conf Biomagn 2001]. We set out to examine what an adequate level of spatial sampling of the brain volume is in a realistic situation, and what implications these inhomogeneities have for region-of-interest analysis. As a basis for these calculations, we used a simple retinotopic mapping experiment where stimuli were 17-Hz reversing gratings presented in either left or right visual hemifield. Beamformer weights were calculated based on the covariance of the MEG data in a 0-80 Hz bandwidth. We then estimated volumetric full-width half-maximum (FWHM) maps at a range of sampling levels. We show that approximately 10% of the 1 mm cubic voxels in the occipital volume have a FWHM smoothness of <5 mm, and 80% <10 mm in three subjects. This was despite relatively low mean signal-to-noise ratios (SNR) values of 1.5. We demonstrate how visualizati...Continue Reading

References

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Citations

Jul 6, 2010·Cerebral Cortex·Leighton B N HinkleyElizabeth A Disbrow
Nov 17, 2010·PloS One·Jennifer B SwettenhamNgoc J Thai
Mar 2, 2013·PloS One·Michael X Cohen, K Richard Ridderinkhof
Apr 16, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Katherine L WheatPeter C Hansen
Jul 4, 2015·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Nicole van KlinkMaeike Zijlmans
Sep 29, 2009·Psychiatry Research·Tony W WilsonDonald C Rojas
Jun 26, 2007·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Douglas CheyneElizabeth W Pang
Feb 25, 2009·Human Brain Mapping·Jan-Mathijs Schoffelen, Joachim Gross
Jan 14, 2011·Human Brain Mapping·Claire M StevensonPeter G Morris
Apr 3, 2012·Hippocampus·Brian R CornwellChristian Grillon
Nov 19, 2010·Human Brain Mapping·Olaf SteinsträterCarsten H Wolters
Sep 5, 2006·Neuropsychologia·Kristen PammerPiers Cornelissen
Jun 15, 2005·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Stephen D HallGareth R Barnes
Oct 16, 2010·NeuroImage·Rebecca E MillmanPhilip T Quinlan
Aug 11, 2010·NeuroImage·Garreth PrendergastGary G R Green
Aug 20, 2014·NeuroImage·Ashwini OswalGareth Barnes
Jun 1, 2016·Frontiers in Human Neuroscience·Marjolein M A EngelsElisabeth C W van Straaten
Jan 31, 2006·International Review of Neurobiology·Alfons Schnitzler, Joachim Gross
Jan 31, 2006·International Review of Neurobiology·Arjan Hillebrand, Gareth R Barnes
Sep 18, 2015·PloS One·Mahmoud HassanFabrice Wendling
Oct 4, 2017·Brain : a Journal of Neurology·Kamalini G RanasingheSrikantan S Nagarajan
Jun 17, 2006·Human Brain Mapping·Francesco Di RussoSteven A Hillyard
Apr 23, 2005·Human Brain Mapping·Arjan HillebrandGareth R Barnes
May 3, 2019·Scientific Reports·Karuna SubramaniamSrikantan S Nagarajan
Apr 7, 2019·Scientific Reports·Kamalini G RanasingheSrikantan S Nagarajan

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