Realizations of highly heterogeneous collagen networks via stochastic reconstruction for micromechanical analysis of tumor cell invasion

Physical Review. E
Hanqing NanYang Jiao

Abstract

Three-dimensional (3D) collective cell migration in a collagen-based extracellular matrix (ECM) is among one of the most significant topics in developmental biology, cancer progression, tissue regeneration, and immune response. Recent studies have suggested that collagen-fiber mediated force transmission in cellularized ECM plays an important role in stress homeostasis and regulation of collective cellular behaviors. Motivated by the recent in vitro observation that oriented collagen can significantly enhance the penetration of migrating breast cancer cells into dense Matrigel which mimics the intravasation process in vivo [Han et al. Proc. Natl. Acad. Sci. USA 113, 11208 (2016)PNASA60027-842410.1073/pnas.1610347113], we devise a procedure for generating realizations of highly heterogeneous 3D collagen networks with prescribed microstructural statistics via stochastic optimization. Specifically, a collagen network is represented via the graph (node-bond) model and the microstructural statistics considered include the cross-link (node) density, valence distribution, fiber (bond) length distribution, as well as fiber orientation distribution. An optimization problem is formulated in which the objective function is defined as the ...Continue Reading

References

Feb 12, 1998·Proceedings of the National Academy of Sciences of the United States of America·R J Pelham, Y l Wang
Dec 17, 1998·Trends in Cell Biology·M E Lukashev, Z Werb
Dec 6, 2003·Science·Anne J RidleyAlan Rick Horwitz
Feb 26, 2004·Proceedings of the National Academy of Sciences of the United States of America·Karoly JakabGabor Forgacs
Dec 2, 2004·Cell Motility and the Cytoskeleton·Tony YeungPaul A Janmey
Feb 21, 2006·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·D A HeadF C MacKintosh
Aug 23, 2006·Cell·Adam J EnglerDennis E Discher
Sep 13, 2006·Macromolecular Bioscience·Joost A J van der RijtJan Feijen
Sep 4, 2007·The European Physical Journal. E, Soft Matter·C Heussinger, E Frey
May 13, 1983·Science·S KirkpatrickM P Vecchi
Oct 13, 2007·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Y JiaoS Torquato
Oct 25, 2007·Biopolymers·Arne EriksonCatharina de Lange Davies
May 6, 2008·Proceedings of the National Academy of Sciences of the United States of America·Sungsoo NaNing Wang
Jun 4, 2008·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Y JiaoS Torquato
Oct 7, 2008·Biophysical Journal·Walter MickelGerd E Schröder-Turk
Dec 31, 2008·Physical Review Letters·M WyartL Mahadevan
Jan 27, 2009·Cell Motility and the Cytoskeleton·Ektoras HadjipanayiRobert A Brown
Feb 7, 2009·Nature Reviews. Molecular Cell Biology·Michele A Wozniak, Christopher S Chen
Feb 7, 2009·Nature Reviews. Molecular Cell Biology·Diana E Jaalouk, Jan Lammerding
Feb 7, 2009·Nature Reviews. Molecular Cell Biology·Ning WangDonald E Ingber
Jun 24, 2009·Nature Reviews. Molecular Cell Biology·Peter Friedl, Darren Gilmour
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Y JiaoS Torquato
Nov 3, 2009·Developmental Cell·Rodrigo Fernandez-GonzalezJennifer A Zallen
Nov 26, 2009·Cell·Kandice R LeventalValerie M Weaver
Oct 5, 2010·PloS One·Robert W TilghmanJ Thomas Parsons
Nov 18, 2010·Biophysical Journal·Triantafyllos StylianopoulosRakesh K Jain
Jan 15, 2011·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Stefan B LindströmDavid A Weitz
Feb 18, 2011·Disease Models & Mechanisms·Thomas R Cox, Janine T Erler
Jul 12, 2011·Annual Review of Cell and Developmental Biology·Thomas LecuitEdwin Munro
Sep 1, 2011·Journal of Physics. Condensed Matter : an Institute of Physics Journal·Avik P Chatterjee
Dec 21, 2011·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Chase E Zachary, Salvatore Torquato
Jun 12, 2012·Physical Review Letters·Yair Shokef, Samuel A Safran
Oct 26, 2012·Biopolymers·Stéphanie Motte, Laura J Kaufman
Apr 9, 2013·Biophysical Journal·Xiaoyue MaRichard T Hart
Jan 1, 2014·Proceedings of the National Academy of Sciences of the United States of America·Quanming ShiJan T Liphardt
Apr 18, 2014·Biophysical Journal·Jieling Zhu, Laura J Kaufman
Oct 8, 2014·Soft Matter·Christopher Allen Rucksack JonesBo Sun
Oct 30, 2014·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·S R GujarathiP M Duxbury
Oct 31, 2014·Nature Reviews. Molecular Cell Biology·Jay D HumphreyMartin A Schwartz

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Citations

Oct 31, 2019·Journal of the Royal Society, Interface·Amots MannAyelet Lesman
Jun 25, 2020·Physical Review. E·Seongjin ParkJessie S Jeon
Jul 9, 2020·Cancer & Metabolism·Elizabeth A BrettDominik Duscher
Feb 13, 2020·Biophysical Journal·Jihan KimBo Sun
May 4, 2021·Biophysical Journal·Yanping LiuLiyu Liu
Apr 29, 2021·Physical Biology·Yanping LiuLiyu Liu
Jun 27, 2021·Biomechanics and Modeling in Mechanobiology·Jonas F EichingerChristian J Cyron
Jan 1, 2019·ACS Biomaterials Science & Engineering·Catalina-Paula SpatareluZi Chen

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