Realizing individualized medicine: the road to translating proteomics from the laboratory to the clinic

Personalized Medicine
Amir RahbarHenry Rodriguez

Abstract

The sequencing of the human genome has brought great promise and potential for the future of medicine, as well as providing a strong momentum for the burgeoning field of individualized medicine. Tests based on genetic information can be used to allow physicians to target therapies for those patients most likely to benefit from specific therapies and identify potential risk before the onset of disease. While advances in genomics-based molecular diagnostics are progressing, producing some useful US FDA-approved/-cleared diagnostic tests, protein-based molecular diagnostics have not met its promised potential. This article will provide an overview of protein-based analysis technologies, identify their strengths and limitations, discuss barriers to protein-based biomarker development and identify issues which must be addressed in order to successfully transfer the field of proteomics from the laboratory to the clinic.

References

Oct 1, 1995·Current Opinion in Structural Biology·J T Stults
Feb 22, 2001·Science·J C VenterX Zhu
Mar 5, 2002·Microbiology and Molecular Biology Reviews : MMBR·Paul R Graves, Timothy A J Haystead
Mar 29, 2002·Acta Haematologica·Bertil JohanssonFelix Mitelman
Dec 19, 2002·Molecular & Cellular Proteomics : MCP·N Leigh Anderson, Norman G Anderson
Apr 30, 2003·Rapid Communications in Mass Spectrometry : RCM·Kornél NagyKároly Vékey
Nov 25, 2003·Hematology·Junia V MeloJane F Apperley
Feb 26, 2004·Journal of Dental Research·Y LiD T W Wong
Oct 22, 2004·Nature·Lincoln D Stein
Nov 6, 2004·Nature Biotechnology·Patrick G A PedrioliRuedi Aebersold
Dec 30, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yang LiDavid T Wong
Feb 8, 2005·Molecular & Cellular Proteomics : MCP·Mathias Uhlen, Fredrik Ponten
Jun 11, 2005·Current Oncology Reports·Brian J Byrne, Jennifer Garst
Jul 14, 2005·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Rafael RosellJose Javier Sanchez
Jul 16, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Amit K GhoshalSteven J Soldin
Dec 8, 2005·Molecular & Cellular Proteomics : MCP·Leigh Anderson, Christie L Hunter
Mar 4, 2006·Expert Review of Molecular Diagnostics·Jiannis Ragoussis, Gareth Elvidge
Apr 15, 2006·Science·Bruno Domon, Ruedi Aebersold
Jul 13, 2006·Archives of Pathology & Laboratory Medicine·Melissa CreggerDavid L Rimm
Jul 22, 2006·Biosensors & Bioelectronics·C T Lim, Y Zhang
Jul 28, 2006·Cold Spring Harbor Symposia on Quantitative Biology·D H GehoR P Araujo
Aug 31, 2006·Clinical Chemistry·Giuseppe LippiGian Cesare Guidi
Dec 26, 2006·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·G Ulrich-MerzenichH Wagner
Jan 5, 2007·Briefings in Functional Genomics & Proteomics·Benito CañasEnrique Calvo
Jan 16, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Faina LinkovRobert L Ferris
Apr 28, 2007·Expert Opinion on Investigational Drugs·Elias JabbourHagop Kantarjian
Jun 2, 2007·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Tetsuya SaitaHiroshi Fujito
Jul 20, 2007·Proteomics·Oda Stoevesandt, Michael J Taussig
Mar 25, 2008·Journal of Immunoassay & Immunochemistry·V TripathiTulsidas G Shrivastav
Jul 12, 2008·Histochemistry and Cell Biology·Axel WalchHeinz Höfler
Aug 23, 2008·Current Opinion in Chemical Biology·Xuemei HanJohn R Yates
Sep 19, 2008·Journal of Proteome Research·Corey E BakalarskiSteven P Gygi
Sep 25, 2008·The Journal of Pathology·E TholouliR J Byers
Dec 2, 2008·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Neil R KitteringhamB Kevin Park
Feb 10, 2009·Combinatorial Chemistry & High Throughput Screening·Simona FranceseGloriano Moneti
Apr 21, 2009·Methods in Molecular Biology·Peter LorenzHans-Jürgen Thiesen

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
ELISA
ELISAs
flow cytometry
peptide array
array technologies
affinity capture
co-immunoprecipitation
protein array

Software Mentioned

SISCAPA
MSQC
mzML
NIST
mzData
CPTC
mzXML

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Expert Review of Molecular Diagnostics
Geoffrey S Ginsburg, Susanne B Haga
Current Topics in Medicinal Chemistry
S A Bapat, G C Mishra
Clinical Pharmacology and Therapeutics
P Cordero, E A Ashley
Movement Disorders Clinical Practice
Lana M Chahine, Matthew B Stern
© 2022 Meta ULC. All rights reserved