Reamed intramedullary femoral nailing after induction of an "ARDS-like" state in sheep: effect on clinically applicable markers of pulmonary function

Journal of Orthopaedic Trauma
P R WolinskyK D Johnson

Abstract

At present, the optimal treatment for appropriately resuscitated, multiply injured patients includes fixation of long bone fractures within twenty-four hours of injury. This management approach has been shown to decrease the incidence of pulmonary complications, multiple organ failure, and death. Some investigators have hypothesized that acute reamed intramedullary nailing of the femur (RIMNF) may result in pulmonary dysfunction as a result of the pulmonary fat embolization generated during this procedure. Patients with concomitant thoracic trauma may be at particular risk for this potentially severe complication. In an attempt to determine whether RIMNF can be safely carried out regardless of the severity of a pulmonary injury, we monitored the pulmonary effects of RIMNF in sheep in which an acute respiratory disorder (ARDS)-like state had been induced. Our hypothesis was that, if the pulmonary fat embolization that occurs as a result of RIMNF has a clinically significant effect, it would be detectable in an animal model in which a severe lung injury had been induced prior to the start of RIMNF. This was an acute experimental procedure performed on yearling sheep. Reamed intramedullary nailing of the femur was performed in two...Continue Reading

References

Feb 1, 1977·The Journal of Trauma·E B RiskaT Paavilainen
Jul 1, 1990·The Journal of Trauma·S W BehrmanJ C Taylor
Feb 1, 1986·Journal of Applied Physiology·E L Dyer, J R Snapper
May 1, 1987·The Journal of Bone and Joint Surgery. British Volume·B Pahud, H Vasey
Dec 1, 1987·The American Review of Respiratory Disease·J W CoggeshallJ R Snapper
Jul 1, 1986·Clinical Nuclear Medicine·A G WilliamsR E Gordon
Jul 1, 1983·American Journal of Surgery·R C TalucciC J Carrico
Nov 1, 1982·The Journal of Trauma·E B Riska, P Myllynen
Jun 1, 1996·The Journal of Trauma·F NeudeckG Schlag

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Citations

Dec 17, 2009·Clinical Orthopaedics and Related Research·Nikolaos G LasanianosPeter V Giannoudis
Jun 10, 2004·Clinical Orthopaedics and Related Research·Steven A Olson
Apr 29, 2009·Journal of Orthopaedic Trauma·Matthew I Rudloff, Wade R Smith
May 8, 2000·The Journal of the American Academy of Orthopaedic Surgeons·R J Brumback, W W Virkus
Sep 23, 2006·Injury·Peter V GiannoudisHans-Christoph Pape
Apr 5, 2011·Injury·N G LasanianosP V Giannoudis

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