PMID: 3760740Sep 1, 1986Paper

Reappearance of the thymus in old rats after orchidectomy: inhibition of regeneration by testosterone

The Journal of Endocrinology
B D GreensteinM J Wheeler

Abstract

The thymus is a critically important organ during development, but atrophies progressively during the ageing process after puberty and is often considered to be unimportant in adult life. We have found that the thymus, which is grossly atrophied in 12- to 15-month-old male rats, is markedly restored in size 30 days after orchidectomy. The organ then appears normal histologically, having a well-defined cortex and medulla, is vascularized and filled with thymocytes. The regeneration of the thymus after orchidectomy was inhibited in a dose-related fashion by testosterone implants which produced serum concentrations of testosterone within the physiological range. The thymus was also increased in size after orchidectomy of 10-week-old rats, and testosterone inhibited the enlargement of the thymus. These results have important implications for the possible enhancement of the immune system with associated improvement of health during ageing and disease. They also point to an important physiological link between the endocrine and immune systems.

Citations

Sep 1, 1990·Cell and Tissue Research·M D KendallA Hamblin
Jan 1, 1991·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·G KuhnP Vecsei
Sep 1, 1988·Mechanisms of Ageing and Development·D R Davila, K W Kelley
Feb 1, 1992·International Journal of Immunopharmacology·J S GilbodyB D Greenstein
May 1, 1992·International Journal of Immunopharmacology·B D GreensteinF T Fitzpatrick
Apr 1, 1992·International Journal of Immunopharmacology·H J SchuurmanJ G Vos
Mar 1, 1995·Molecular and Cellular Endocrinology·S M ViselliW J Kovacs
Apr 1, 1988·Domestic Animal Endocrinology·T H Wise
Jun 1, 1990·Brain, Behavior, and Immunity·O A BatumanB H Natelson
May 1, 1993·The Journal of Steroid Biochemistry and Molecular Biology·N J OlsenW J Kovacs
Jun 18, 2005·Seminars in Immunology·Valerie P Zediak, Avinash Bhandoola
Jun 1, 1997·Obstetrics and Gynecology·C C HsuK E Huang
Dec 18, 2001·Mechanisms of Ageing and Development·Gordana LeposavicDusko Kosec
Jun 1, 2000·Developmental and Comparative Immunology·G MorónM C Pistoresi-Palencia
Oct 26, 1999·Journal of Reproductive Immunology·K F Windmill, V W Lee
Aug 27, 1998·The Journal of Steroid Biochemistry and Molecular Biology·T Wise
Feb 2, 2010·Cellular & Molecular Immunology·Serani L H van DommelenLi Wu
Sep 5, 2001·Clinical and Experimental Immunology·J Pido-LopezR Aspinall
Feb 28, 2004·Journal of Anti-aging Medicine·Gregory M Fahy
Nov 30, 2006·Annual Review of Immunology·Lisbeth A WelniakWilliam J Murphy
May 23, 2008·Journal of Leukocyte Biology·Amanda L Gruver, Gregory D Sempowski
Jul 24, 2010·Canadian Journal of Physiology and Pharmacology·Hacène FrihAbdel Majid Bairi
Oct 1, 1998·International Journal of Immunopharmacology·P P SfikakisD Mitropoulos
Mar 28, 1998·Leukemia & Lymphoma·A MiadonnaG Lambertenghi Deliliers
Aug 24, 1999·Immunological Investigations·J L RosenS M Viselli
Dec 26, 1992·Annals of the New York Academy of Sciences·R BrunelliG Doria
Nov 25, 2003·Microscopy Research and Technique·Lourdes Domínguez-Gerpe, Manuel Rey-Méndez
May 9, 2012·Seminars in Immunology·Ivan K ChinnGregory D Sempowski
Jul 7, 2009·Immunobiology·Milica PerisićGordana Leposavić
Jul 18, 2009·Current Opinion in Immunology·Amanda M Holland, Marcel R M van den Brink
Jun 20, 2008·Experimental Gerontology·Richard Aspinall, Wayne Mitchell
Oct 30, 2007·Seminars in Immunology·Gabrielle L GoldbergMarcel R M van den Brink
Jan 1, 1996·Advances in Neuroimmunology·R L Mosley
Mar 30, 2012·Birth Defects Research. Part C, Embryo Today : Reviews·Joëlle A BaddourPanagiotis A Tsonis
Feb 26, 2008·Cellular Immunology·Melanie HinceAnn Chidgey
Jan 1, 1988·Annals of the New York Academy of Sciences·K W KelleyS Arkins
Sep 29, 2005·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Hyeyoung MinKenneth Dorshkind
Jun 22, 2005·Seminars in Immunology·Encarnacion Montecino-RodriquezKenneth Dorshkind

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