Reappearance of viral hemorrhagic fever with renal syndrome in northwestern Greece

International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
N AkritidisG Pappas

Abstract

Minor outbreaks of viral hemorrhagic fever (VHF) with renal failure have occurred in northwestern Greece over past decades. However, during the most recent decade, there has been a paucity of human cases despite the detection of hantavirus in rodents of this area. We present herein the cases of two patients with VHF, arising in the same area, hospitalized for a short period of time. One patient presented with renal failure, while severe hepatic involvement was predominant in the other. Significantly high ELISA antibody titers for hantavirus established the diagnosis. Supportive treatment led to a successful outcome in both cases. We further discuss the difficulties in differential diagnosis of VHF from other zoonoses with similar endemicity, such as leptospirosis. Awareness of the continuing presence of VHF in rural Greece is needed, and a rapid diagnosis is important for the correct therapeutic approach. Continuous surveillance for such diseases, at both the animal (rodents) and human level, is warranted.

References

Jan 1, 1992·American Journal of Nephrology·K C SiamopoulosH M Moutsopoulos
Jul 1, 1993·Journal of Clinical Gastroenterology·M ElisafK C Siamopoulos
Oct 25, 2003·Clinical Rheumatology·G PappasE Tsianos
Dec 4, 2003·The Lancet Infectious Diseases·Jan ClementMarc Van Ranst
Jan 28, 2006·The Lancet Infectious Diseases·Georgios PappasEpameinondas V Tsianos
May 19, 2006·Emerging Infectious Diseases·Anna PapaAntonis Antoniadis
Aug 8, 2006·International Journal of Antimicrobial Agents·Lampros RaptisNikolaos Akritidis
Nov 7, 2006·International Journal of Antimicrobial Agents·Georgios Pappas, Antonio Cascio

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Citations

Sep 8, 2011·The American Journal of Tropical Medicine and Hygiene·Suneth B AgampodiJoseph M Vinetz
Sep 14, 2012·Theoretical Population Biology·Zeljka Lončarić, Branimir K Hackenberger
Nov 10, 2010·PloS One·Karthik ViswanathanRam Sasisekharan

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