Reappraisal of BCL3 as a molecular marker of anaplastic large cell lymphoma

International Journal of Hematology
Hitoshi OhnoHironori Haga

Abstract

The BCL3 gene was initially discovered through its involvement in a recurring translocation, t(14;19)(q32;q13), which is found in some patients with B-cell chronic lymphocytic leukemia (B-CLL). The translocation leads to the juxtaposition of BCL3 to the immunoglobulin heavy chain gene locus, resulting in high-level expression of the BCL3 transcript. The Bcl-3 protein includes 7 tandem copies of the ankyrin repeat element in the central domain, a structure that is characteristic of the IkappaB family of inhibitors of the nuclear factor kappaB transcription factors. Anaplastic large cell lymphoma (ALCL) is a subtype of aggressive non-Hodgkin's lymphoma that is characterized by expression of CD30 and the NPM/ALK chimeric protein, which is generated by t(2;5)(p23;q35). We compared the gene expression profiles of ALCL with those of another CD30+ neoplasm, Hodgkin's disease (HD), and found that BCL3 is expressed at higher levels in ALCL than in HD. A comparison by real-time polymerase chain reaction assay revealed that t(2;5)+ ALCL expresses a high level of BCL3 messenger RNA relative to the levels expressed in other hematologic tumors, and the level in ALCL is comparable to or even higher than that in t(14;19)+ B-CLL. An immunohisto...Continue Reading

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Citations

Dec 22, 2007·Nature Reviews. Cancer·Roberto ChiarleGiorgio Inghirami
Aug 23, 2008·Biochimica Et Biophysica Acta·Mridula NambiarSathees C Raghavan
Jul 15, 2011·European Journal of Haematology·Hazem A H IbrahimKikkeri N Naresh
Nov 19, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xiaoren ZhangUlrich Siebenlist

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