PMID: 590697Jan 1, 1977

Reappraisal of cholesterol solubilization in bile salt-lecithin solution and the stability of bile

Gastroenterologia Japonica
T FurusawaT Hisadome

Abstract

On the basis obtained in a preceding study, cholesterol solubilization in aqueous bile salt-lecithin solution was investigated. The alteration of mixing sequence was found to yield differences not only in the rate but also in the magnitude of cholesterol solubilization. Both the rate and the magnitude were remarkably bigger in the system solubilizing cholesterol and lecithin mixture by bile salt than that solubilizing cholesterol crystal by bile salt with solubilized lecithin. A linear relation between the quantity of solubilized cholesterol and the concentration of bile salt except for lower concentration range was obtained for every bile salt-lecithin system. Values of k, the slope of the partial straight line, determined for cholate, chenodeoxycholate, deoxycholate and equimolar cholate-deoxycholate systems were 5.85 X 10(-2), 7.60 X 10(-2), 9.50 X 10(-2) and 7.17 X 10(-2), respectively. Cholesterol solubilizing power of bile salt was thus enhanced by the addition of lecithin. Since the solubilizing power could be given by the ratio of the solubilizate to the solubilizer, it was expressed graphically by the ratio of cholesterol to bile salt as ordinate and the concentration of bile salt as abscissa. The saturability of chole...Continue Reading

References

Jan 1, 1976·Gastroenterologia Japonica·T FurusawaH Itoh
Jun 1, 1973·The Journal of Clinical Investigation·R T HolzbachK Holan
Jun 1, 1973·Journal of Pharmaceutical Sciences·W I HiguchiF Young
Aug 1, 1973·The American Journal of Digestive Diseases·N TamesueK Juniper
Mar 1, 1974·The American Journal of Digestive Diseases·L SwellZ R Vlahcevic
Jul 1, 1974·The American Journal of Digestive Diseases·B W TrotmanR D Soloway
Mar 1, 1974·Journal of Pharmaceutical Sciences·D MufsonL J Ravin
Apr 1, 1971·Annals of Surgery·C K McSherryF Glenn
Jul 7, 1972·Biochimica Et Biophysica Acta·D H Neiderhiser, H P Roth
Jul 1, 1971·American Journal of Surgery·F Nakayama, W van der Linden
Apr 1, 1971·Zeitschrift für Ernährungswissenschaft·F G Hegardt, H Dam
Jan 1, 1967·Annual Review of Medicine·A F Hofmann, D M Small
May 1, 1968·The Journal of Clinical Investigation·W H Admirand, D M Small
May 1, 1968·Proceedings of the Society for Experimental Biology and Medicine·D H Neiderhiser, H P Roth
Jun 10, 1969·Biochimica Et Biophysica Acta·D R Saunders, M A Wells
Aug 1, 1966·Clinica Chimica Acta; International Journal of Clinical Chemistry·F Nakayama
Feb 14, 1967·Biochimica Et Biophysica Acta·M BourgèsD G Dervichian

Citations

Jan 1, 1980·Gastroenterologia Japonica·T HisadomeT Furusawa

Related Concepts

Biliary Sludge
Bile Salts
Epicholesterol
Phosphatidylcholines
Solutions

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.