PMID: 16532197Mar 15, 2006Paper

Reappraisal of experimental infections with cercariae and schistosomula of a Brazilian strain of Schistosoma mansoni in mice

Brazilian Journal of Biology = Revista Brasleira De Biologia
M M Vilar, R M Pinto

Abstract

The present investigation involves a reevaluation of previous results obtained after experimental infection of Swiss Webster mice with cercariae and schistosomula of the Schistosoma mansoni LE strain maintained under laboratory conditions. Three experimental groups of mice were considered: the animals of the first group were percutaneously (ring method) infected with cercariae, those of the second were subcutaneously inoculated with cercariae and the mice of the third were inoculated by the same route with schistosomula transformed in vitro. The data obtained so far indicated that the most effective method of infection is the subcutaneous injection with schistosomula, with a mean adult worm burden recovery of 54.1% when compared to the abdominal percutaneous and subcutaneous routes of infection with cercariae, in which the values were 36.7% and 32.4%, respectively. This suggests that, in experimental infections of SW mice with a LE S. mansoni strain, the skin is to be considered an effective attrition site in the percutaneous route, whereas in the case of inoculation with cercariae, a small amount of larvae fails to be transformed into viable schistosomula, possibly due to skin phase avoidance. A brief discussion about attritio...Continue Reading

References

Jan 1, 1990·Memórias do Instituto Oswaldo Cruz·R M PintoM Tendler
May 1, 1985·Revista Do Instituto De Medicina Tropical De São Paulo·M TendlerG Gebara

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Citations

Sep 21, 2018·Frontiers in Immunology·Camila O S SouzaLúcia H Faccioli
Mar 7, 2021·Parasitology International·Michélia A N GusmãoPriscila de Faria-Pinto

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