Reappraisal of H2S/sulfide concentration in vertebrate blood and its potential significance in ischemic preconditioning and vascular signaling

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Nathan L WhitfieldKenneth R Olson

Abstract

Hydrogen sulfide (H(2)S) is rapidly emerging as a biologically significant signaling molecule. Studies published before 2000 report low or undetectable H(2)S (usually as total sulfide) levels in blood or plasma, whereas recent work has reported sulfide concentrations between 10 and 300 microM, suggesting it acts as a circulating signal. In the first series of experiments, we used a recently developed polarographic sensor to measure the baseline level of endogenous H(2)S gas and turnover of exogenous H(2)S gas in real time in blood from numerous animals, including lamprey, trout, mouse, rat, pig, and cow. We found that, contrary to recent reports, H(2)S gas was essentially undetectable (<100 nM total sulfide) in all animals. Furthermore, exogenous sulfide was rapidly removed from blood, plasma, or 5% bovine serum albumin in vitro and from intact trout in vivo. To determine if blood H(2)S could transiently increase, we measured oxygen-dependent H(2)S production by trout hearts in vitro and in vivo. H(2)S has been shown to mediate ischemic preconditioning (IPC) in mammals. IPC is present in trout and, unlike mammals, the trout myocardium obtains its oxygen from relatively hypoxic systemic venous blood. In vitro, myocardial H(2)S p...Continue Reading

References

Jan 1, 1990·Archives of Toxicology·M W WarenyciaR J Reiffenstein
Nov 1, 1967·The Journal of Cell Biology·V T Marchesi, G E Palade
Jul 1, 1967·Quarterly Journal of Experimental Physiology and Cognate Medical Sciences·C L Evans
Nov 20, 1998·The American Journal of Gastroenterology·M D LevittF L Suarez
Feb 9, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·T M HoaglandK R Olson
Mar 16, 2001·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·J F Steffensen, A P Farrell
Nov 14, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·A K GamperlA P Farrell
Nov 1, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Rui Wang
Dec 28, 2002·The Journal of Experimental Biology·A P Farrell, S M Clutterham
May 18, 2004·Biochemical and Biophysical Research Communications·Bin GengChaoshu Tang
May 4, 2005·Analytical Biochemistry·Jeannette E DoellerDavid W Kraus
Oct 29, 2005·The Journal of Physiology·Philip I AaronsonJeremy P T Ward
Feb 10, 2006·Journal of Applied Physiology·Charles W LefflerRui Wang
Feb 21, 2006·Current Opinion in Pharmacology·Ling LiPhilip K Moore
Jul 22, 2006·Experimental Physiology·Paul J Kemp
Aug 5, 2006·The Journal of Experimental Biology·Ryan A DombkowskiKenneth R Olson
Oct 7, 2006·The Journal of Experimental Biology·Kenneth R OlsonJane A Madden
Oct 14, 2006·Journal of Applied Physiology·Yi Zhun ZhuPhilip K Moore
Jan 24, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Jeffrey R KoenitzerDavid W Kraus
Jul 17, 2007·Neurochemistry International·K QuP T-H Wong
Sep 22, 2007·Trends in Pharmacological Sciences·John L Wallace
Oct 4, 2007·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Antonio M Morselli-LabateRaffaele Pezzilli
Oct 20, 2007·Nature Reviews. Drug Discovery·Csaba Szabó
Oct 1, 2007·Medical Journal, Armed Forces India·R M SharmaS Mahajan

❮ Previous
Next ❯

Citations

Jul 20, 2011·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Robert C Hider, Xiao L Kong
Jun 12, 2013·Respiratory Physiology & Neurobiology·Philippe Haouzi, Candice M Klingerman
Sep 11, 2013·Proceedings of the National Academy of Sciences of the United States of America·Roberta d'Emmanuele di Villa BiancaRaffaella Sorrentino
May 8, 2010·The Journal of Biological Chemistry·Omer Kabil, Ruma Banerjee
Nov 27, 2009·Antioxidants & Redox Signaling·Mayumi KajimuraMakoto Suematsu
Sep 23, 2009·Antioxidants & Redox Signaling·David R LindenJoseph H Szurszewski
Sep 4, 2010·Antioxidants & Redox Signaling·Li-Fang HuJin-Song Bian
Oct 28, 2010·Antioxidants & Redox Signaling·Rasmus Wedel NielsenJakob Rahr Winther
Oct 30, 2010·Antioxidants & Redox Signaling·Frédéric Bouillaud, François Blachier
Feb 7, 2012·Antioxidants & Redox Signaling·Yi-Hong LiuJin-Song Bian
Jan 11, 2012·Antioxidants & Redox Signaling·Victor VitvitskyRuma Banerjee
Nov 15, 2011·Antioxidants & Redox Signaling·Kenneth R Olson
Jan 12, 2012·Antioxidants & Redox Signaling·Andry Van de Louw, Philippe Haouzi
Jul 28, 2010·Cardiovascular Research·Qian-Chen YongJin-Song Bian
Aug 6, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Alessandra F PernaNatale G De Santo
May 28, 2011·Shock·Eric J NorrisMark G Clemens
Feb 13, 2010·Clinical and Experimental Pharmacology & Physiology·Ming-Jie WangYi-Chun Zhu
Nov 6, 2008·Acta Physiologica·A BogdanovaM Nikinmaa
Nov 6, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kenneth R OlsonJane A Madden
Oct 8, 2011·Circulation Research·Asif K MustafaSolomon H Snyder
Oct 4, 2012·Critical Care : the Official Journal of the Critical Care Forum·Andry Van de Louw, Philippe Haouzi
Dec 1, 2012·Critical Care : the Official Journal of the Critical Care Forum·Enrico CalziaKenneth R Olson
Apr 18, 2012·PloS One·Ernesto CuevasantaMatías N Möller
Dec 4, 2012·Sensors·Hanjing PengBinghe Wang
Jan 15, 2014·Biochimica Et Biophysica Acta·Omer KabilRuma Banerjee
Jun 17, 2014·Nitric Oxide : Biology and Chemistry·Xinggui ShenChristopher G Kevil
Jul 18, 2014·Annual Review of Nutrition·Omer KabilRuma Banerjee
Jun 15, 2014·Nitric Oxide : Biology and Chemistry·Kenneth R OlsonFang Liu
Jul 19, 2014·Thorax·Junpei SaitoKian Fan Chung
Jan 8, 2011·Annual Review of Pharmacology and Toxicology·Ling LiPhilip K Moore
Mar 22, 2014·Nitric Oxide : Biology and Chemistry·Oscar McCookUlrich Wachter
Jun 17, 2014·Nitric Oxide : Biology and Chemistry·Rudolf WedmannMilos R Filipovic
Jul 3, 2013·Nutrition Reviews·Yves Ingenbleek, Hideo Kimura
Mar 2, 2013·Journal of the American Society of Nephrology : JASN·Eelke M BosHarry van Goor
Oct 5, 2011·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·L G Forgan, M E Forster
Nov 26, 2015·Expert Opinion on Drug Discovery·Vincenzo CalderoneMaria C Breschi
Oct 30, 2012·Biochemical Pharmacology·Khosrow Kashfi, Kenneth R Olson
Nov 29, 2013·Kidney International·Kai SongLi-Fang Hu
Apr 12, 2012·Respiratory Physiology & Neurobiology·Andry Van de Louw, Philippe Haouzi
Sep 10, 2010·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Alessandra F PernaNatale G De Santo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Julie FurneMichael D Levitt
American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Kenneth R OlsonSteve F Perry
American Journal of Physiology. Heart and Circulatory Physiology
Jeffrey KoenitzerDavid W Kraus
© 2022 Meta ULC. All rights reserved