Reappraisal of HER2 status in the spectrum of advanced urothelial carcinoma: a need of guidelines for treatment eligibility

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
Anissa MoktefiYves Allory

Abstract

Although human epidermal growth factor receptor 2 (HER2) may represent a therapeutic target, its evaluation in urothelial carcinoma of the bladder does not rely on a standardized scoring system by immunohistochemistry or fluorescent in situ hybridization (FISH), as reflected by various methodology in the literature and clinical trials. Our aim was to improve and standardize HER2 amplification detection in bladder cancer. We assessed immunohistochemical criteria derived from 2013 American Society of Clinical Oncology (ASCO)/College of American Pathologists (CAPs) guidelines for breast cancer and investigated intratumoral heterogeneity in a retrospective multicentric cohort of 188 patients with locally advanced urothelial carcinoma of the bladder. Immunohistochemistry was performed on 178 primary tumors and 126 lymph node metastases, eligible cases (moderate/strong, complete/incomplete membrane staining) were assessed by FISH. HER2 overexpression was more frequent with 2013 ASCO/CAP than 2007 ASCO/CAP guidelines (p < 0.0001). The rate of positive HER2 FISH was similar between primary tumor and lymph node metastases (8%). Among positive FISH cases, 48% were associated with moderate/strong incomplete membrane staining that were not...Continue Reading

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Citations

Feb 13, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Simone BertzAntje Knöll
Dec 20, 2018·Histopathology·Antonio Lopez-BeltranLiang Cheng
Jun 15, 2021·American Journal of Clinical Pathology·Sambit K MohantyAnil V Parwani
Sep 30, 2021·Experimental and Therapeutic Medicine·Ying-Hsu ChangSee-Tong Pang
Oct 7, 2021·The Journal of Pathology·Nanor SirabYves Allory

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