Reappraisal of metallothionein: Clinical implications for patients with diabetes mellitus

Journal of Diabetes
Yongsoo ParkLu Cai

Abstract

Reactive oxygen and nitrogen species (ROS and RNS, respectively) are byproducts of cellular physiological processes of the metabolism of intermediary nutrients. Although physiological defense mechanisms readily convert these species into water or urea, an improper balance between their production and removal leads to oxidative stress (OS), which is harmful to cellular components. This OS may result in uncontrolled growth or, ultimately, cell death. In addition, ROS and RNS are closely related to the development of diabetes and its complications. Therefore, numerous researchers have proposed the development of strategies for the removal of ROS/RNS to prevent or treat diabetes and its complications. Some molecules that are synthesized in the body or obtained from food participate in the removal and neutralization of ROS and RNS. Metallothionein, a cysteine-rich protein, is a metal-binding protein that has a wide range of functions in cellular homeostasis and immunity. Metallothionein can be induced by a variety of conditions, including zinc supplementation, and plays a crucial role in mediating anti-OS, anti-apoptotic, detoxification, and anti-inflammatory effects. Metallothionein can modulate various stress-induced signaling pat...Continue Reading

References

May 1, 1989·Toxicology Letters·J Abel, N de Ruiter
Jan 1, 1987·Experientia. Supplementum·I BremnerM Sato
Sep 1, 1994·Environmental Health Perspectives·C D KlaassenW C Kershaw
Oct 11, 1996·The American Journal of Physiology·R C De LisleG K Andrews
Oct 15, 1996·Archives of Biochemistry and Biophysics·A R QuesadaD H Petering
Jul 1, 1997·Comparative Biochemistry and Physiology. Part A, Physiology·D M Cohen
Jan 23, 1999·The Journal of Clinical Investigation·M IgarashiG L King
Jul 31, 1999·FEBS Letters·A SakuraiN Imura
Apr 8, 2000·Critical Reviews in Biochemistry and Molecular Biology·A T MilesV Rodilla
Aug 6, 2000·Free Radical Biology & Medicine·K HensleyR A Floyd
Oct 24, 2000·The Journal of Biological Chemistry·L CaiY J Kang
Dec 29, 2000·Journal of Toxicology and Environmental Health. Part a·M T WuH Hu
Feb 13, 2001·Kidney International·C Guijarro, J Egido
Feb 28, 2001·Proceedings of the National Academy of Sciences of the United States of America·B YeB L Vallee
Nov 2, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·T PurvesD R Tomlinson
May 23, 2002·Cellular and Molecular Life Sciences : CMLS·P CoyleA M Rofe
Sep 6, 2002·Biochemical Pharmacology·Linda VermeulenGuy Haegeman
Apr 18, 2003·Toxicological Sciences : an Official Journal of the Society of Toxicology·Ryuya ShimodaMichael P Waalkes
Oct 16, 2003·Molecular and Cellular Biology·Ann-Hwee LeeLaurie H Glimcher
Feb 13, 2004·The New England Journal of Medicine·Kitt Falk PetersenGerald I Shulman
Dec 22, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Irina G ObrosovaCsaba Szabó
Sep 17, 2005·BMC Immunology·Xiuyun YinMichael A Lynes
Oct 21, 2005·The Biochemical Journal·Sarah K BairdUlf T Brunk
Oct 26, 2005·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Milan Vasák
Dec 3, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Liang ChenMonica Nordberg
Jan 25, 2006·Physiology & Behavior·Edward D LevinJonathan H Freedman

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