Reappraisal of the interplay between psychosis and depression symptoms in the pathogenesis of psychotic syndromes: results from a twenty-year prospective community study.

European Archives of Psychiatry and Clinical Neuroscience
W RösslerV Ajdacic-Gross

Abstract

The interplay of psychotic and affective symptoms is a crucial challenge in understanding the pathogenesis of psychosis. In this study, we analyzed the interplay between two subclinical psychosis symptoms dimensions, and one depression symptoms dimension, using longitudinal data from Zurich. The Zurich study started in 1979 with a representative sample of 591 participants who were aged 20/21. Follow-up interviews were conducted at age 23, 28, 30, 35, and 41. The psychiatric symptoms were assessed with a semi-structured interview and the SCL 90-R. In this study, we analyzed three SCL-90-R subscales: the depression symptoms dimension and two distinct symptoms dimensions of subclinical psychosis, one representing a schizophrenia nuclear symptom dimension, the other representing a schizotypal symptoms dimension. Modeling was done with hybrid latent growth models, thereby including simultaneous and cross-lagged effects. The interplay between the two subclinical psychosis symptoms dimensions and the depression symptoms dimension includes several intertwined pathways. The schizotypal symptoms dimension has strong direct effects on the schizophrenia nuclear symptoms dimension, but also on the depression symptoms dimension. The latter h...Continue Reading

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Citations

Jan 19, 2011·European Archives of Psychiatry and Clinical Neuroscience·H J Möller, P Falkai
Aug 27, 2011·BMJ : British Medical Journal·Kathleen R MerikangasJules Angst
May 29, 2012·Schizophrenia Research·Wulf RösslerJules Angst
Sep 30, 2015·Journal of Addiction·Simon ZhornitskyStéphane Potvin
Dec 28, 2018·Psychiatry and Clinical Neurosciences·Hwagyu SuhYoung In Chung
Jul 28, 2011·European Archives of Psychiatry and Clinical Neuroscience·Evelina HaralanovaKristina Hennig-Fast
Jan 7, 2019·Psychiatry Research·Antonio PretiDonatella Rita Petretto

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