Reappraising Risk Factors for Inflammatory Bowel Disease-associated Neoplasia: Implications for Colonoscopic Surveillance in IBD.

Journal of Crohn's & Colitis
Shailja C Shah, Steven H Itzkowitz

Abstract

One of the most feared complications of inflammatory bowel disease [IBD]-associated colitis is colorectal cancer. When considering the substantial increase in the prevalence of IBD, without any anticipated decline, coupled with decreasing colectomy rates for dysplasia and expanding medical options for effectively controlling inflammation, it is predicted that the pool of people living with-and ageing with-colonic IBD, who are recommended to undergo lifelong colonoscopic surveillance for colorectal neoplasia, will strain existing resources and challenge the sustainability of current guideline-based surveillance recommendations. At the same time, we are missing the opportunity for early detection in a group that is overlooked as high-risk, as a substantial proportion of colorectal cancers are being diagnosed in individuals with colonic IBD who have disease duration shorter than when guidelines recommend surveillance initiation. Here, we reappraise: 1] inflammation as a dynamic risk factor that considers patients' cumulative course; 2] time of screening initiation that is not based primarily on absolute disease duration; and 3] surveillance intervals as an iterative determination based on individual patient factors and consecutive...Continue Reading

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Citations

Jun 12, 2020·Therapeutic Advances in Gastroenterology·Jordan E Axelrad, Shailja C Shah
Mar 26, 2021·Clinical Medicine : Journal of the Royal College of Physicians of London·Jonathan P SegalAilsa L Hart
Jan 12, 2021·Journal of Crohn's & Colitis·Michel AdaminaMagali Svrcek

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