Rearing by foster Wistar mother with high level of maternal care counteracts the development of genetic absence epilepsy and comorbid depression in WAG/Rij rats

Doklady Biological Sciences : Proceedings of the Academy of Sciences of the USSR, Biological Sciences Sections
K Yu SarkisovaA A Morosov

Abstract

It has been shown for the first time that rearing by a foster Wistar mother with high level of maternal care (MC) counteracts the expression of genetic absence epilepsy (AE) and comorbid depression - reduces the number, duration and index of spike-wave discharges (SWDs) and immobility time in the forced swimming test, as well as exerts substantial effects on morphology and time-frequency dynamics of SWDs in WAG/Rij rats. It is supposed that increases in MC early in development might be used to counteract epileptogenesis and comorbid depression in people genetically predisposed to AE.

References

Nov 20, 2001·Bulletin of Experimental Biology and Medicine·G S YakobsonM G Yakobson
Sep 27, 2005·Behavioural Brain Research·K Yu Sarkisova, M A Kulikov
Jul 3, 2008·Pharmacology, Biochemistry, and Behavior·O MalkesmanA Weizman
Nov 26, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Karine Sarkisova, Gilles van Luijtelaar
Oct 13, 2012·The British Journal of Psychiatry : the Journal of Mental Science·Ruth SellersAnita Thapar
Jul 28, 2016·Behavioural Brain Research·Petra MajdakJustin S Rhodes

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Citations

Apr 1, 2018·Genes, Brain, and Behavior·K Y Sarkisova, A V Gabova
Aug 15, 2020·Frontiers in Behavioral Neuroscience·Aymen BalikciNurbay Ates
Oct 22, 2020·Doklady Biological Sciences : Proceedings of the Academy of Sciences of the USSR, Biological Sciences Sections·K Yu SarkisovaA B Shatskova
Oct 17, 2020·Brain Research Bulletin·Evgenia Sitnikova, Kirill Smirnov

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