Rearrangement-enhancing element upstream of the mouse immunoglobulin kappa chain J cluster

Science
L FerradiniJ C Weill

Abstract

Transcriptional regulatory elements have been shown to be necessary but not sufficient for the developmental regulation of immunoglobulin gene rearrangement in mouse precursor B cells. In the chicken lambda light chain locus, additional elements in the V-J intervening sequence are involved in negative and positive regulation of rearrangement. Here, mutation of the mouse homolog of a chicken element, located in the V(K)-J(K) intervening sequence upstream of the J(K) cluster, was shown to significantly decrease rearrangement. This cis-acting recombination-enhancing element affects the rearrangement process without being involved in regulating transcription.

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Citations

Aug 13, 1998·Developmental and Comparative Immunology·J C Weill, C A Reynaud
Dec 30, 1999·Veterinary Immunology and Immunopathology·R AitkenR MacDuff
Apr 1, 1997·Current Opinion in Immunology·R Kühn, F Schwenk
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Jan 1, 2009·Proceedings of the National Academy of Sciences of the United States of America·Benjamin TaylorMatthias Merkenschlager
Jan 1, 2009·Proceedings of the National Academy of Sciences of the United States of America·Rupesh H AminMark S Schlissel
Nov 7, 2003·Nucleic Acids Research·Philipp OberdoerfferKlaus Rajewsky
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Aug 24, 2010·Immunological Reviews·Christian Vettermann, Mark S Schlissel
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Aug 28, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Zhe LiuWilliam T Garrard
Nov 16, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xiaorong ZhouWilliam T Garrard
Apr 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hiromu SatoAkira Kudo
May 6, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yougui Xiang, William T Garrard
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Jan 7, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·S LiW T Garrard

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